TY - JOUR
T1 - Acute Phase Response as a Biological Mechanism-of-Action of (Nano)particle-Induced Cardiovascular Disease
AU - Hadrup, Niels
AU - Zhernovkov, Vadim
AU - Jacobsen, Nicklas Raun
AU - Voss, Carola
AU - Strunz, Maximilian
AU - Ansari, Meshal
AU - Schiller, Herbert B.
AU - Halappanavar, Sabina
AU - Poulsen, Sarah S.
AU - Kholodenko, Boris
AU - Stoeger, Tobias
AU - Saber, Anne Thoustrup
AU - Vogel, Ulla Birgitte
PY - 2020
Y1 - 2020
N2 - Inhaled nanoparticles constitute a potential health hazard due to their size-dependent lung deposition and large surface to mass ratio. Exposure to high levels contributes to the risk of developing respiratory and cardiovascular diseases, as well as of lung cancer. Particle-induced acute phase response may be an important mechanism of action of particle-induced cardiovascular disease. Here, the authors review new important scientific evidence showing causal relationships between inhalation of particle and nanomaterials, induction of acute phase response, and risk of cardiovascular disease. Particle-induced acute phase response provides a means for risk assessment of particle-induced cardiovascular disease and underscores cardiovascular disease as an occupational disease.
AB - Inhaled nanoparticles constitute a potential health hazard due to their size-dependent lung deposition and large surface to mass ratio. Exposure to high levels contributes to the risk of developing respiratory and cardiovascular diseases, as well as of lung cancer. Particle-induced acute phase response may be an important mechanism of action of particle-induced cardiovascular disease. Here, the authors review new important scientific evidence showing causal relationships between inhalation of particle and nanomaterials, induction of acute phase response, and risk of cardiovascular disease. Particle-induced acute phase response provides a means for risk assessment of particle-induced cardiovascular disease and underscores cardiovascular disease as an occupational disease.
U2 - 10.1002/smll.201907476
DO - 10.1002/smll.201907476
M3 - Journal article
C2 - 32227434
SN - 1613-6810
VL - 16
JO - Small
JF - Small
IS - 21
M1 - 1907476
ER -
