Activation of Toll-like Receptor 2 in Human Synovium Explants Increase Tissue Turnover and Secretion of Interleukin-6

Neha Sharma; Ashref Kayed; Cecilie Freja Kjelgaard-Petersen; Thorbjorn G. Christiansen; Morten Karsdal; Christian S. Thudium; Anne-C Bay-Jensen

Activation of Toll-like Receptor 2 in Human Synovium Explants Increase Tissue Turnover and Secretion of Interleukin-6

Neha Sharma
, Ashref Kayed
, Cecilie Freja Kjelgaard-Petersen
, Thorbjorn G. Christiansen
, Morten Karsdal
, Christian S. Thudium
, Anne-C Bay-Jensen

University of Copenhagen
Gentofte University Hospital
Nordic Bioscience AS

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

178 Downloads (Orbit)

Abstract

Background/Purpose:
The innate immune system is important for initiation and development of OA. Increased degradation of the cartilage release fragments into the synovial fluid, which can then bind to innate immune receptors in the synovium. The aim of this study was to investigate the effect of Toll like receptor 2 (TLR2) activation by synthetic agonists and a synthetic aggrecan 32 amino acid fragment (32-mer) on the tissue turnover and IL-6 secretion, in a human synovial membrane explant model.

Original language	English
Article number	1063
Journal	Arthritis and Rheumatology
Volume	69
Number of pages	4
ISSN	2326-5205
Publication status	Published - 2017
Event	2017 ACR/ARHP Annual Meeting - San Diego, United States Duration: 3 Nov 2017 → 8 Nov 2017 http://acrabstracts.org/meetings/2017-acrarhp-annual-meeting/

Conference

Conference	2017 ACR/ARHP Annual Meeting
Country/Territory	United States
City	San Diego
Period	03/11/2017 → 08/11/2017
Internet address	http://acrabstracts.org/meetings/2017-acrarhp-annual-meeting/

Access to Document

Acrabstracts org abstract activation of toll like receptor 2Final published version, 1.02 MB

OpenUrl availability

Check availability in DTU Findit

Cite this

@article{18804d228c3748258d5185fefa599091,

title = "Activation of Toll-like Receptor 2 in Human Synovium Explants Increase Tissue Turnover and Secretion of Interleukin-6",

abstract = "Background/Purpose: The innate immune system is important for initiation and development of OA. Increased degradation of the cartilage release fragments into the synovial fluid, which can then bind to innate immune receptors in the synovium. The aim of this study was to investigate the effect of Toll like receptor 2 (TLR2) activation by synthetic agonists and a synthetic aggrecan 32 amino acid fragment (32-mer) on the tissue turnover and IL-6 secretion, in a human synovial membrane explant model.",

author = "Neha Sharma and Ashref Kayed and Kjelgaard-Petersen, \{Cecilie Freja\} and Christiansen, \{Thorbjorn G.\} and Morten Karsdal and Thudium, \{Christian S.\} and Anne-C Bay-Jensen",

year = "2017",

language = "English",

volume = "69",

journal = "Arthritis and Rheumatology",

issn = "2326-5205",

publisher = "John Wiley and Sons Ltd",

note = "2017 ACR/ARHP Annual Meeting ; Conference date: 03-11-2017 Through 08-11-2017",

url = "http://acrabstracts.org/meetings/2017-acrarhp-annual-meeting/",

}

TY - ABST

T1 - Activation of Toll-like Receptor 2 in Human Synovium Explants Increase Tissue Turnover and Secretion of Interleukin-6

AU - Sharma, Neha

AU - Kayed, Ashref

AU - Kjelgaard-Petersen, Cecilie Freja

AU - Christiansen, Thorbjorn G.

AU - Karsdal, Morten

AU - Thudium, Christian S.

AU - Bay-Jensen, Anne-C

PY - 2017

Y1 - 2017

N2 - Background/Purpose: The innate immune system is important for initiation and development of OA. Increased degradation of the cartilage release fragments into the synovial fluid, which can then bind to innate immune receptors in the synovium. The aim of this study was to investigate the effect of Toll like receptor 2 (TLR2) activation by synthetic agonists and a synthetic aggrecan 32 amino acid fragment (32-mer) on the tissue turnover and IL-6 secretion, in a human synovial membrane explant model.

AB - Background/Purpose: The innate immune system is important for initiation and development of OA. Increased degradation of the cartilage release fragments into the synovial fluid, which can then bind to innate immune receptors in the synovium. The aim of this study was to investigate the effect of Toll like receptor 2 (TLR2) activation by synthetic agonists and a synthetic aggrecan 32 amino acid fragment (32-mer) on the tissue turnover and IL-6 secretion, in a human synovial membrane explant model.

M3 - Conference abstract in journal

SN - 2326-5205

VL - 69

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

M1 - 1063

T2 - 2017 ACR/ARHP Annual Meeting

Y2 - 3 November 2017 through 8 November 2017

ER -

Activation of Toll-like Receptor 2 in Human Synovium Explants Increase Tissue Turnover and Secretion of Interleukin-6

Abstract

Conference

Access to Document

OpenUrl availability

Fingerprint

Cite this