Abstract
Background/Purpose:
The innate immune system is important for initiation and development of OA. Increased degradation of the cartilage release fragments into the synovial fluid, which can then bind to innate immune receptors in the synovium. The aim of this study was to investigate the effect of Toll like receptor 2 (TLR2) activation by synthetic agonists and a synthetic aggrecan 32 amino acid fragment (32-mer) on the tissue turnover and IL-6 secretion, in a human synovial membrane explant model.
The innate immune system is important for initiation and development of OA. Increased degradation of the cartilage release fragments into the synovial fluid, which can then bind to innate immune receptors in the synovium. The aim of this study was to investigate the effect of Toll like receptor 2 (TLR2) activation by synthetic agonists and a synthetic aggrecan 32 amino acid fragment (32-mer) on the tissue turnover and IL-6 secretion, in a human synovial membrane explant model.
| Original language | English |
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| Article number | 1063 |
| Journal | Arthritis and Rheumatology |
| Volume | 69 |
| Number of pages | 4 |
| ISSN | 2326-5205 |
| Publication status | Published - 2017 |
| Event | 2017 ACR/ARHP Annual Meeting - San Diego, United States Duration: 3 Nov 2017 → 8 Nov 2017 http://acrabstracts.org/meetings/2017-acrarhp-annual-meeting/ |
Conference
| Conference | 2017 ACR/ARHP Annual Meeting |
|---|---|
| Country/Territory | United States |
| City | San Diego |
| Period | 03/11/2017 → 08/11/2017 |
| Internet address |