Activation of Toll-like Receptor 2 in Human Synovium Explants Increase Tissue Turnover and Secretion of Interleukin-6

Neha Sharma, Ashref Kayed, Cecilie Freja Kjelgaard-Petersen, Thorbjorn G. Christiansen, Morten Karsdal, Christian S. Thudium, Anne-C Bay-Jensen

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Abstract

Background/Purpose:
The innate immune system is important for initiation and development of OA. Increased degradation of the cartilage release fragments into the synovial fluid, which can then bind to innate immune receptors in the synovium. The aim of this study was to investigate the effect of Toll like receptor 2 (TLR2) activation by synthetic agonists and a synthetic aggrecan 32 amino acid fragment (32-mer) on the tissue turnover and IL-6 secretion, in a human synovial membrane explant model.
Original languageEnglish
Article number1063
JournalArthritis and Rheumatology
Volume69
Number of pages4
ISSN2326-5205
Publication statusPublished - 2017
Event2017 ACR/ARHP Annual Meeting - San Diego, United States
Duration: 3 Nov 20178 Nov 2017
http://acrabstracts.org/meetings/2017-acrarhp-annual-meeting/

Conference

Conference2017 ACR/ARHP Annual Meeting
CountryUnited States
CitySan Diego
Period03/11/201708/11/2017
Internet address

Cite this

Sharma, N., Kayed, A., Kjelgaard-Petersen, C. F., Christiansen, T. G., Karsdal, M., Thudium, C. S., & Bay-Jensen, A-C. (2017). Activation of Toll-like Receptor 2 in Human Synovium Explants Increase Tissue Turnover and Secretion of Interleukin-6. Arthritis and Rheumatology, 69, [1063].