Activation and Transfer of the Chromosomal Phage Resistance Mechanism AbiV in Lactococcus lactis

J. Haaber, S. Moineau, Karin Hammer

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    AbiV is a chromosomally encoded phage resistance mechanism that is silent in the wild-type phage-sensitive strain Lactococcus lactis subsp. cremoris MG1363. Spontaneous phage-resistant mutants of L. lactis MG1363 were analyzed by reverse transcriptase PCR and shown to express AbiV. This expression was related to a reorganization in the upstream region of abiV. Transfer of abiV between two lactococcal strains, most likely by conjugation, was also demonstrated. To our knowledge, this is the first report of natural transfer of a chromosomally encoded phage resistance mechanism.
    Original languageEnglish
    JournalApplied and Environmental Microbiology
    Volume75
    Issue number10
    Pages (from-to)3358-3361
    ISSN0099-2240
    DOIs
    Publication statusPublished - 2009

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