ACTINOMYCIN D ANALOGUES

Glenn Tong (Inventor), John Nielsen (Inventor)

    Research output: Patent

    Abstract

    The present invention relates to new compounds being structurally and functionally similar to Actinomycin D and to combinatorial libraries of such compounds. The Actinomycin D analogues according to the present invention comprise two linear or cyclic peptide moieties constituted by $g(a)-amino acids, $g(b)-amino acids and/or longer chain $g(v)-amino acids, and a difunctional group which preferably is a cyclic entity, in particular, an aromatic or heteroaromatic entity acting as an intercalator group. Specific compounds and a library of such compounds may be prepared using conventional solid phase peptide synthesis (SPPS) methodologies. The novel compounds are expected to have affinity for DNA and RNA, and libraries thereof may therefore advantageously be used for screening purposes. Furthermore, a novel double-combinatorial technique that may be used in the preparation of librairies of broader classes of compounds has been developed.
    Original languageEnglish
    Patent numberWO/1997/010263
    Filing date20/03/1997
    CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
    Publication statusPublished - 1997

    Bibliographical note

    51 pages

    Cite this

    Tong, G., & Nielsen, J. (1997). ACTINOMYCIN D ANALOGUES. (Patent No. WO/1997/010263).
    Tong, Glenn (Inventor) ; Nielsen, John (Inventor). / ACTINOMYCIN D ANALOGUES. Patent No.: WO/1997/010263. Mar 20, 1997.
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    abstract = "The present invention relates to new compounds being structurally and functionally similar to Actinomycin D and to combinatorial libraries of such compounds. The Actinomycin D analogues according to the present invention comprise two linear or cyclic peptide moieties constituted by $g(a)-amino acids, $g(b)-amino acids and/or longer chain $g(v)-amino acids, and a difunctional group which preferably is a cyclic entity, in particular, an aromatic or heteroaromatic entity acting as an intercalator group. Specific compounds and a library of such compounds may be prepared using conventional solid phase peptide synthesis (SPPS) methodologies. The novel compounds are expected to have affinity for DNA and RNA, and libraries thereof may therefore advantageously be used for screening purposes. Furthermore, a novel double-combinatorial technique that may be used in the preparation of librairies of broader classes of compounds has been developed.",
    author = "Glenn Tong and John Nielsen",
    note = "51 pages; WO/1997/010263",
    year = "1997",
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    Tong, G & Nielsen, J Mar. 20 1997, ACTINOMYCIN D ANALOGUES, Patent No. WO/1997/010263.

    ACTINOMYCIN D ANALOGUES. / Tong, Glenn (Inventor); Nielsen, John (Inventor).

    Patent No.: WO/1997/010263. Mar 20, 1997.

    Research output: Patent

    TY - PAT

    T1 - ACTINOMYCIN D ANALOGUES

    AU - Tong, Glenn

    AU - Nielsen, John

    N1 - 51 pages

    PY - 1997

    Y1 - 1997

    N2 - The present invention relates to new compounds being structurally and functionally similar to Actinomycin D and to combinatorial libraries of such compounds. The Actinomycin D analogues according to the present invention comprise two linear or cyclic peptide moieties constituted by $g(a)-amino acids, $g(b)-amino acids and/or longer chain $g(v)-amino acids, and a difunctional group which preferably is a cyclic entity, in particular, an aromatic or heteroaromatic entity acting as an intercalator group. Specific compounds and a library of such compounds may be prepared using conventional solid phase peptide synthesis (SPPS) methodologies. The novel compounds are expected to have affinity for DNA and RNA, and libraries thereof may therefore advantageously be used for screening purposes. Furthermore, a novel double-combinatorial technique that may be used in the preparation of librairies of broader classes of compounds has been developed.

    AB - The present invention relates to new compounds being structurally and functionally similar to Actinomycin D and to combinatorial libraries of such compounds. The Actinomycin D analogues according to the present invention comprise two linear or cyclic peptide moieties constituted by $g(a)-amino acids, $g(b)-amino acids and/or longer chain $g(v)-amino acids, and a difunctional group which preferably is a cyclic entity, in particular, an aromatic or heteroaromatic entity acting as an intercalator group. Specific compounds and a library of such compounds may be prepared using conventional solid phase peptide synthesis (SPPS) methodologies. The novel compounds are expected to have affinity for DNA and RNA, and libraries thereof may therefore advantageously be used for screening purposes. Furthermore, a novel double-combinatorial technique that may be used in the preparation of librairies of broader classes of compounds has been developed.

    M3 - Patent

    M1 - WO/1997/010263

    Y2 - 1997/03/20

    ER -

    Tong G, Nielsen J, inventors. ACTINOMYCIN D ANALOGUES. WO/1997/010263. 1997.