Accurate approximation method for prediction of class I MHC affinities for peptides of length 8, 10 and 11 using prediction tools trained on 9mers

Claus Lundegaard, Ole Lund, Morten Nielsen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Several accurate prediction systems have been developed for prediction of class I major histocompatibility complex (MHC):peptide binding. Most of these are trained on binding affinity data of primarily 9mer peptides. Here, we show how prediction methods trained on 9mer data can be used for accurate binding affinity prediction of peptides of length 8, 10 and 11. The method gives the opportunity to predict peptides with a different length than nine for MHC alleles where no such peptides have been measured. As validation, the performance of this approach is compared to predictors trained on peptides of the peptide length in question. In this validation, the approximation method has an accuracy that is comparable to or better than methods trained on a peptide length identical to the predicted peptides.
    Original languageEnglish
    JournalBioinformatics
    Volume24
    Issue number11
    Pages (from-to)1397-1398
    ISSN1367-4803
    DOIs
    Publication statusPublished - 2008

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