Accelerating the implementation of biocatalysis in industry

John M. Woodley*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Despite enormous progress in protein engineering, complemented by bioprocess engineering, the revolution awaiting the application of biocatalysis in the fine chemical industry has still not been fully realized. In order to achieve that, further research is required on several topics, including (1) rapid methods for protein engineering using machine learning, (2) mathematical modelling of multi-enzyme cascade processes, (3) process standardization, (4) continuous process technology, (5) methods to identify improvements required to achieve industrial implementation, (6) downstream processing, (7) enzyme stability modelling and prediction, as well as (8) new reactor technology. In this brief mini-review, the status of each of these topics will be briefly discussed.
Original languageEnglish
JournalApplied Microbiology and Biotechnology
Volume103
Issue number12
Pages (from-to)4733–4739
ISSN0175-7598
DOIs
Publication statusPublished - 2019

Keywords

  • Biocatalysis
  • Enzymatic conversion

Cite this

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title = "Accelerating the implementation of biocatalysis in industry",
abstract = "Despite enormous progress in protein engineering, complemented by bioprocess engineering, the revolution awaiting the application of biocatalysis in the fine chemical industry has still not been fully realized. In order to achieve that, further research is required on several topics, including (1) rapid methods for protein engineering using machine learning, (2) mathematical modelling of multi-enzyme cascade processes, (3) process standardization, (4) continuous process technology, (5) methods to identify improvements required to achieve industrial implementation, (6) downstream processing, (7) enzyme stability modelling and prediction, as well as (8) new reactor technology. In this brief mini-review, the status of each of these topics will be briefly discussed.",
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Accelerating the implementation of biocatalysis in industry. / Woodley, John M.

In: Applied Microbiology and Biotechnology, Vol. 103, No. 12, 2019, p. 4733–4739.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Accelerating the implementation of biocatalysis in industry

AU - Woodley, John M.

PY - 2019

Y1 - 2019

N2 - Despite enormous progress in protein engineering, complemented by bioprocess engineering, the revolution awaiting the application of biocatalysis in the fine chemical industry has still not been fully realized. In order to achieve that, further research is required on several topics, including (1) rapid methods for protein engineering using machine learning, (2) mathematical modelling of multi-enzyme cascade processes, (3) process standardization, (4) continuous process technology, (5) methods to identify improvements required to achieve industrial implementation, (6) downstream processing, (7) enzyme stability modelling and prediction, as well as (8) new reactor technology. In this brief mini-review, the status of each of these topics will be briefly discussed.

AB - Despite enormous progress in protein engineering, complemented by bioprocess engineering, the revolution awaiting the application of biocatalysis in the fine chemical industry has still not been fully realized. In order to achieve that, further research is required on several topics, including (1) rapid methods for protein engineering using machine learning, (2) mathematical modelling of multi-enzyme cascade processes, (3) process standardization, (4) continuous process technology, (5) methods to identify improvements required to achieve industrial implementation, (6) downstream processing, (7) enzyme stability modelling and prediction, as well as (8) new reactor technology. In this brief mini-review, the status of each of these topics will be briefly discussed.

KW - Biocatalysis

KW - Enzymatic conversion

U2 - 10.1007/s00253-019-09796-x

DO - 10.1007/s00253-019-09796-x

M3 - Journal article

VL - 103

SP - 4733

EP - 4739

JO - Applied Microbiology and Biotechnology

JF - Applied Microbiology and Biotechnology

SN - 0175-7598

IS - 12

ER -