Abstract CT103: Final results for OptimalTTF-1: Optimizing Tumor Treating Fields with targeted skull remodeling surgery for first recurrence glioblastoma: Phase 1 trial

Nikola Mikic; Anders Rosendal Korshoej; Slávka Lukacova; Jens Christian Hedemann Sørensen; Frederik Lundgaard Hansen; Axel Thielscher; Søren Cortnum; Trine Lignell Guldberg; Yasmin Lassen-Ramshad; Christian Rahbek; Kare Eg Severinsen; Gorm von Oettingen

doi:10.1158/1538-7445.AM2020-CT103

Abstract CT103: Final results for OptimalTTF-1: Optimizing Tumor Treating Fields with targeted skull remodeling surgery for first recurrence glioblastoma: Phase 1 trial

Nikola Mikic, Anders Rosendal Korshoej, Slávka Lukacova, Jens Christian Hedemann Sørensen, Frederik Lundgaard Hansen, Axel Thielscher, Søren Cortnum, Trine Lignell Guldberg, Yasmin Lassen-Ramshad, Christian Rahbek, Kare Eg Severinsen, Gorm von Oettingen

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Abstract

We present a clinical open label, phase-1 trial (OptimalTTF-1, NCT02893137), which aims to test a novel treatment for first recurrence glioblastoma (rGBM). The aim of the treatment is to optimize the electric field generated by Tumor Treating Fields (TTFields) with targeted and individualized skull-remodeling surgery (SR-surgery). Selectively placed burrholes reduces the electric resistance created by the bone and thus improves the electric field focally. Preclinical research has indicated this conclusion. The final analysis examined the toxicity and efficacy of this combined intervention in addition to best practice chemotherapy.

Original language	English
Article number	CT103
Journal	Cancer Research
Volume	80
Issue number	16, suppl.
ISSN	0008-5472
DOIs	https://doi.org/10.1158/1538-7445.AM2020-CT103
Publication status	Published - 2020
Event	AACR Annual Meeting 2020 - Online, Philadelphia, United States Duration: 27 Apr 2020 → 28 Apr 2020

Conference

Conference	AACR Annual Meeting 2020
Location	Online
Country/Territory	United States
City	Philadelphia
Period	27/04/2020 → 28/04/2020

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Mikic, N., Korshoej, A. R., Lukacova, S., Sørensen, J. C. H., Lundgaard Hansen, F., Thielscher, A., Cortnum, S., Guldberg, T. L., Lassen-Ramshad, Y., Rahbek, C., Severinsen, K. E., & von Oettingen, G. (2020). Abstract CT103: Final results for OptimalTTF-1: Optimizing Tumor Treating Fields with targeted skull remodeling surgery for first recurrence glioblastoma: Phase 1 trial. Cancer Research, 80(16, suppl.), [CT103]. https://doi.org/10.1158/1538-7445.AM2020-CT103

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title = "Abstract CT103: Final results for OptimalTTF-1: Optimizing Tumor Treating Fields with targeted skull remodeling surgery for first recurrence glioblastoma: Phase 1 trial",

abstract = "We present a clinical open label, phase-1 trial (OptimalTTF-1, NCT02893137), which aims to test a novel treatment for first recurrence glioblastoma (rGBM). The aim of the treatment is to optimize the electric field generated by Tumor Treating Fields (TTFields) with targeted and individualized skull-remodeling surgery (SR-surgery). Selectively placed burrholes reduces the electric resistance created by the bone and thus improves the electric field focally. Preclinical research has indicated this conclusion. The final analysis examined the toxicity and efficacy of this combined intervention in addition to best practice chemotherapy.",

author = "Nikola Mikic and Korshoej, {Anders Rosendal} and Sl{\'a}vka Lukacova and S{\o}rensen, {Jens Christian Hedemann} and {Lundgaard Hansen}, Frederik and Axel Thielscher and S{\o}ren Cortnum and Guldberg, {Trine Lignell} and Yasmin Lassen-Ramshad and Christian Rahbek and Severinsen, {Kare Eg} and {von Oettingen}, Gorm",

year = "2020",

doi = "10.1158/1538-7445.AM2020-CT103",

language = "English",

volume = "80",

journal = "Cancer research. Supplement",

issn = "0576-6656",

publisher = "American Association for Cancer Research (A A C R)",

number = "16, suppl.",

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Mikic, N, Korshoej, AR, Lukacova, S, Sørensen, JCH, Lundgaard Hansen, F, Thielscher, A, Cortnum, S, Guldberg, TL, Lassen-Ramshad, Y, Rahbek, C, Severinsen, KE & von Oettingen, G 2020, 'Abstract CT103: Final results for OptimalTTF-1: Optimizing Tumor Treating Fields with targeted skull remodeling surgery for first recurrence glioblastoma: Phase 1 trial', Cancer Research, vol. 80, no. 16, suppl., CT103. https://doi.org/10.1158/1538-7445.AM2020-CT103

Abstract CT103: Final results for OptimalTTF-1: Optimizing Tumor Treating Fields with targeted skull remodeling surgery for first recurrence glioblastoma: Phase 1 trial. / Mikic, Nikola; Korshoej, Anders Rosendal; Lukacova, Slávka et al.
In: Cancer Research, Vol. 80, No. 16, suppl., CT103, 2020.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

TY - ABST

T1 - Abstract CT103: Final results for OptimalTTF-1: Optimizing Tumor Treating Fields with targeted skull remodeling surgery for first recurrence glioblastoma: Phase 1 trial

AU - Mikic, Nikola

AU - Korshoej, Anders Rosendal

AU - Lukacova, Slávka

AU - Sørensen, Jens Christian Hedemann

AU - Lundgaard Hansen, Frederik

AU - Thielscher, Axel

AU - Cortnum, Søren

AU - Guldberg, Trine Lignell

AU - Lassen-Ramshad, Yasmin

AU - Rahbek, Christian

AU - Severinsen, Kare Eg

AU - von Oettingen, Gorm

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AB - We present a clinical open label, phase-1 trial (OptimalTTF-1, NCT02893137), which aims to test a novel treatment for first recurrence glioblastoma (rGBM). The aim of the treatment is to optimize the electric field generated by Tumor Treating Fields (TTFields) with targeted and individualized skull-remodeling surgery (SR-surgery). Selectively placed burrholes reduces the electric resistance created by the bone and thus improves the electric field focally. Preclinical research has indicated this conclusion. The final analysis examined the toxicity and efficacy of this combined intervention in addition to best practice chemotherapy.

U2 - 10.1158/1538-7445.AM2020-CT103

DO - 10.1158/1538-7445.AM2020-CT103

M3 - Conference abstract in journal

SN - 0576-6656

VL - 80

JO - Cancer research. Supplement

JF - Cancer research. Supplement

IS - 16, suppl.

M1 - CT103

T2 - AACR Annual Meeting 2020

Y2 - 27 April 2020 through 28 April 2020

ER -

Abstract CT103: Final results for OptimalTTF-1: Optimizing Tumor Treating Fields with targeted skull remodeling surgery for first recurrence glioblastoma: Phase 1 trial

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