Absorption, conjugation and excretion of the flavanones, naringenin and hesperetin from alpha-rhamnosidase-treated orange juice in human subjects

Lea Bredsdorff, I.L.F. Nielsen, S.E. Rasmussen, C. Cornett, D. Barron, F. Bouisset, E. Offord, G. Williamson

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We have determined the absorption, conjugation and excretion of naringenin-7-O-rutinosicle (narirutin) compared to the corresponding glucoside in an orange juice matrix in human subjects. Healthy volunteers (eight men and eight women), in a double blind, randomised, crossover study, consumed orange juice with (1) natural content of naringenin-7-O-rutinoside; (2) alpha-rhamnosidase-treated to yield naringenin-7-O-glucoside. Blood was sampled at twelve time points and three fractions of urine were collected over 24 h. The area under the plasma-time curve of naringenin from (2) alpha-rhamnosidase-treated orange juice was increased about 4-fold (P
Original languageEnglish
JournalBritish Journal of Nutrition
Volume103
Issue number11
Pages (from-to)1602-1609
ISSN0007-1145
DOIs
Publication statusPublished - 2010

Keywords

  • Bioavailability
  • Citrus fruits
  • Hesperetin
  • Metabolism
  • Naringenin

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