Ability for anaerobic growth is not sufficient for development of the petite phenotype in Saccharomyces kluyveri

Kasper Møller, Lisbeth Olsson, Jure Piskur

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Saccharomyces cerevisiae is a petite-phenotype-positive ("petite-positive") yeast, which can successfully grow in the absence of oxygen. On the other hand, Kluyveromyces lactis as well as many other yeasts are petite negative and cannot grow anaerobically. In this paper, we show that Saccharomyces kluyveri can grow under anaerobic conditions, but while it can generate respiration-deficient mutants, it cannot generate true petite mutants. From a phylogenetic point of view, S. kluyveri is apparently more closely related to S. cerevisiae than to K. lactis. These observations suggest that the progenitor of the modern Saccharomyces and Kluyveromyces yeasts, as well as other related genera, was a petite-negative and aerobic yeast. Upon separation of the K. lactis and S. kluyveri-S. cerevisiae lineages, the latter developed the ability to grow anaerobically. However, while the S. kluyveri lineage has remained petite negative, the lineage leading to the modern Saccharomyces sensu stricto and sensu late yeasts has developed the petite-positive characteristic.
    Original languageEnglish
    JournalJournal of Bacteriology
    Volume183
    Issue number8
    Pages (from-to)2485-2489
    ISSN0021-9193
    Publication statusPublished - 2001

    Keywords

    • cpb
    • yeastn

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