Abdominal obesity and fatty liver

Marianne Uhre Jakobsen, T. Berentzen, T. I. A. Sorensen, K. Overvad

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

It has been hypothesized that visceral fat releases free fatty acids and adipokines and thereby exposes the liver to fat accumulation. The authors aimed to evaluate current epidemiologic evidence for an association between abdominal fat and liver fat content. Clinical and epidemiologic studies with data on abdominal fat and liver fat content were reviewed. Studies using waist circumference to estimate abdominal fat mass suggested a direct association between abdominal fat and liver fat content. Studies using imaging methods suggested a direct association between intraabdominal fat and liver fat content, but not between subcutaneous abdominal fat and liver fat content. In conclusion, clinical and epidemiologic studies of abdominal fat and liver fat content suggest a direct association between abdominal fat and liver fat content which is probably accounted for by visceral fat. However, results from the included studies do not allow strong conclusions regarding the temporal sequence of events. Future longitudinal studies are recommended to obtain additional information on associations and mechanisms. Both abdominal fat depots and other body compartments of interest should be included to further investigate the association between specific fat depots and liver fat content. Biomarkers may provide insight into underlying mechanisms.
Original languageEnglish
JournalEpidemiologic Reviews
Volume29
Issue number1
Pages (from-to)77-87
Number of pages11
ISSN1478-6729
DOIs
Publication statusPublished - 2007
Externally publishedYes

Keywords

  • Abdominal Fat
  • Denmark
  • Fatty Liver
  • Humans
  • Obesity
  • Epidemiology
  • Abdominal fat
  • Adiposity
  • Fatty liver
  • Intra-abdominal fat
  • Subcutaneous fat, abdominal
  • adipocytokine
  • biological marker
  • fatty acid
  • abdominal obesity
  • fatty liver
  • human
  • imaging system
  • intraabdominal fat
  • longitudinal study
  • nonalcoholic fatty liver
  • priority journal
  • review
  • subcutaneous fat
  • systematic review
  • waist circumference
  • PUBLIC,
  • ALANINE AMINOTRANSFERASE ACTIVITY
  • NONALCOHOLIC HEPATIC STEATOSIS
  • BODY-MASS INDEX
  • INSULIN-RESISTANCE
  • VISCERAL FAT
  • CAROTID ATHEROSCLEROSIS
  • WAIST CIRCUMFERENCE
  • METABOLIC SYNDROME
  • ADIPOSE-TISSUE
  • HEALTHY-MEN
  • abdominal fat
  • adiposity
  • intra-abdominal fat
  • obesity
  • abdominal
  • Biochemistry studies - Lipids
  • Nutrition - General studies, nutritional status and methods
  • Digestive system - Physiology and biochemistry
  • Digestive system - Pathology
  • Animals, Chordates, Humans, Mammals, Primates, Vertebrates
  • temporal sequence

Cite this

Jakobsen, M. U., Berentzen, T., Sorensen, T. I. A., & Overvad, K. (2007). Abdominal obesity and fatty liver. Epidemiologic Reviews, 29(1), 77-87. https://doi.org/10.1093/epirev/mxm002