Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation

Terje Svingen, Annemiek Beverdam, Pali Verma, Dagmar Wilhelm, Peter Koopman

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Aard (alanine and arginine rich domain) is a gene of unknown function, previously reported to show sexually dimorphic expression in fetal mouse gonads. Here we describe the spatio-temporal expression profile of Aard during gonad development. The period of elevated mRNA expression coincides with early differentiation of the testis and is limited to Sertoli cells of the developing testis cords. Although low levels of Aard transcripts were detected in other tissues by quantitative RT-PCR assays, high levels of Aard expression is specific to the testis in both embryonic and adult mice.
Original languageEnglish
JournalInternational Journal of Developmental Biology
Volume51
Issue number3
Pages (from-to)255-258
Number of pages4
ISSN0214-6282
DOIs
Publication statusPublished - 2007
Externally publishedYes

Keywords

  • Alanine
  • Animals
  • Arginine
  • Crosses, Genetic
  • DNA, Complementary
  • In Situ Hybridization
  • Male
  • Mice
  • Mice, Inbred Strains
  • Organ Specificity
  • Protein Structure, Tertiary
  • Proteins
  • RNA, Messenger
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sertoli Cells
  • Testis
  • Time Factors
  • Tissue Distribution
  • Up-Regulation
  • Aard protein, mouse
  • 94ZLA3W45F Arginine
  • OF5P57N2ZX Alanine
  • aard gene
  • animal tissue
  • article
  • controlled study
  • embryo cell
  • gene
  • gene expression
  • gene location
  • gonad development
  • male
  • mouse
  • nonhuman
  • nucleotide sequence
  • priority journal
  • reverse transcription polymerase chain reaction
  • Sertoli cell
  • sex differentiation
  • upregulation
  • Mus
  • Aard
  • gonad
  • Sex differentiation
  • Testis cord
  • DEVELOPMENTAL
  • SEX DETERMINATION REVEALS
  • GENE-EXPRESSION
  • GERM-CELLS
  • XX
  • aard
  • testis cord
  • cell differentiation
  • Rodentia Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Mammals, Nonhuman Vertebrates, Nonhuman Mammals, Rodents, Vertebrates) - Muridae [86375] mouse common adult, fetus
  • mouse Aard gene [Muridae] mouse alanine and arginine rich domain gene expression, regulation
  • mRNA messenger RNA expression
  • 02506, Cytology - Animal
  • 03502, Genetics - General
  • 03506, Genetics - Animal
  • 10062, Biochemistry studies - Nucleic acids, purines and pyrimidines
  • 16504, Reproductive system - Physiology and biochemistry
  • 17002, Endocrine - General
  • 17006, Endocrine - Gonads and placenta
  • 25502, Development and Embryology - General and descriptive
  • Biochemistry and Molecular Biophysics
  • Reproduction
  • gonad reproductive system, endocrine system
  • Sertoli cell reproductive system
  • testis reproductive system
  • Development
  • Molecular Genetics
  • Reproductive System

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