A whole-body multi-scale mathematical model for dynamic simulation of the metabolism in man

Peter Emil Carstensen, Jacob Bendsen, Asbjørn Thode Reenberg, Tobias K. S. Ritschel, John Bagterp Jorgensen

Research output: Contribution to journalConference articleResearchpeer-review

43 Downloads (Pure)

Abstract

We propose a whole-body model of the metabolism in man as well as a generalized approach for modeling metabolic networks. Using this approach, we are able to write a large metabolic network in a systematic and compact way. We demonstrate the approach using a whole-body model of the metabolism of the three macronutrients, carbohydrates, proteins and lipids. The model contains 7 organs, 16 metabolites and 31 enzymatic reactions. All reaction rates are described by Michaelis-Menten kineties with an addition of a hormonal regulator based on the two hormones insulin and glucagon. We incorporate ingestion of food in order to simulate metabolite concentrations during the feed-fast cycle. The model can simulate several days due to the inclusion of storage forms (glycogen, musele protein and lipid droplets), that can be depleted if food is not ingested regularly. A physiological model incorporating complex cellular metabolism and whole-body mass dynamics can be used in virtual clinical trials. Such trials can be used to improve the development of medicine, treatment strategies such as control algorithms, and increase the likelihood of a successful clinical trial.
Original languageEnglish
Book seriesIFAC-PapersOnLine
Volume55
Issue number23
Pages (from-to)58-63
ISSN2405-8963
DOIs
Publication statusPublished - 2022
Event9th IFAC Conference on Foundations of Systems Biology in Engineering : FOSBE 2022 - Cambridge, United States
Duration: 28 Aug 202231 Aug 2022

Conference

Conference9th IFAC Conference on Foundations of Systems Biology in Engineering
Country/TerritoryUnited States
CityCambridge
Period28/08/202231/08/2022

Keywords

  • Mathematical modeling
  • Metabolism
  • System biology
  • Cyber-medical systems
  • Multi-scale modeling
  • Quantitative system pharmacology

Fingerprint

Dive into the research topics of 'A whole-body multi-scale mathematical model for dynamic simulation of the metabolism in man'. Together they form a unique fingerprint.

Cite this