A tunable freeform-segmented reflector in a microfluidic system for conventional and surface-enhanced raman spectroscopy

Qing Liu, Michael Stenbæk Schmidt, Hugo Thienpont, Heidi Ottevaere*

*Corresponding author for this work

    Research output: Contribution to journalJournal articleResearchpeer-review

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    Abstract

    We present a freeform-segmented reflector-based microfluidic system for conventional Raman and Surface-Enhanced Raman Scattering (SERS) analysis. The segmented reflector is directly designed by a numerical approach. The polymer-based Raman system strongly suppresses the undesirable background because it enables confocal detection of Raman scattering through the combination of a freeform reflector and a microfluidic chip. We perform systematic simulations using non-sequential ray tracing with the Henyey-Greenstein model to assess the Raman scattering behavior of the substance under test. We fabricate the freeform reflector and the microfluidic chip by means of ultra-precision diamond turning and laser cutting respectively. We demonstrate the confocal behavior by measuring the Raman spectrum of ethanol. Besides, we calibrate the setup by performing Raman measurements on urea and potassium nitrate solutions with different concentrations. The detection limit of our microfluidic system is approximately 20 mM according to the experiment. Finally, we implement a SERS microfluidic chip and discriminate 100 μM urea and potassium nitrate solutions.

    Original languageEnglish
    Article number1250
    JournalSensors (Switzerland)
    Volume20
    Issue number5
    Number of pages15
    ISSN1424-8220
    DOIs
    Publication statusPublished - 1 Mar 2020

    Keywords

    • Freeform surface
    • Microfluidics
    • Optical detection
    • Photonics
    • Raman spectroscopy
    • SERS

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