A systematic synthesis and design methodology to achieve process intensification in (bio) chemical processes

Philip Lutze; Alicia Román-Martinez; John Woodley; Rafiqul Gani

doi:10.1016/S1570-7946(10)28041-0

A systematic synthesis and design methodology to achieve process intensification in (bio) chemical processes

Philip Lutze, Alicia Román-Martinez, John Woodley, Rafiqul Gani

Department of Chemical and Biochemical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

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Abstract

Process intensification (PI) has the potential to improve existing processes or create new process options which are needed in order to produce products using more sustainable methods. PI creates an enormous number of process options. In order to manage the complexity of options in which a feasible and optimal process solution may exist, the application of process synthesis tools results in the development of a systematic methodology to implement PI. Starting from an analysis of existing processes, this methodology generates a set of feasible process options and reduces their number through a number of screening steps until from the remaining feasible options, the optimal is found. The application of this systematic methodology through a computer-aided framework is presented through a case study, the chemo-enzymatic synthesis of N-acetyl-D-neuraminic acid (Neu5Ac).

Original language	English
Title of host publication	Proceedings of the 20th European Symposium on Computer Aided Process Engineering
Publisher	Elsevier
Publication date	2010
Pages	241-246
ISBN (Print)	04-44-53569-1, 978-0-444-53569-6
DOIs	https://doi.org/10.1016/S1570-7946(10)28041-0
Publication status	Published - 2010
Event	20th European Symposium on Computer Aided Process Engineering - Ischia, Italy Duration: 6 Jun 2010 → 9 Jun 2010 Conference number: 20 http://www.aidic.it/escape20/

Conference

Conference	20th European Symposium on Computer Aided Process Engineering
Number	20
Country/Territory	Italy
City	Ischia
Period	06/06/2010 → 09/06/2010
Internet address	http://www.aidic.it/escape20/

Series	Computer Aided Chemical Engineering
Volume	28
ISSN	1570-7946

Keywords

Methodology
Process synthesis
Process intensification
Biocatalysis
N-acetylneuraminic acid (Neu5Ac)

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title = "A systematic synthesis and design methodology to achieve process intensification in (bio) chemical processes",

abstract = "Process intensification (PI) has the potential to improve existing processes or create new process options which are needed in order to produce products using more sustainable methods. PI creates an enormous number of process options. In order to manage the complexity of options in which a feasible and optimal process solution may exist, the application of process synthesis tools results in the development of a systematic methodology to implement PI. Starting from an analysis of existing processes, this methodology generates a set of feasible process options and reduces their number through a number of screening steps until from the remaining feasible options, the optimal is found. The application of this systematic methodology through a computer-aided framework is presented through a case study, the chemo-enzymatic synthesis of N-acetyl-D-neuraminic acid (Neu5Ac). ",

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Lutze, P, Román-Martinez, A, Woodley, J & Gani, R 2010, A systematic synthesis and design methodology to achieve process intensification in (bio) chemical processes. in Proceedings of the 20th European Symposium on Computer Aided Process Engineering. Elsevier, Computer Aided Chemical Engineering, vol. 28, pp. 241-246, 20th European Symposium on Computer Aided Process Engineering, Ischia, Italy, 06/06/2010. https://doi.org/10.1016/S1570-7946(10)28041-0

A systematic synthesis and design methodology to achieve process intensification in (bio) chemical processes. / Lutze, Philip; Román-Martinez, Alicia; Woodley, John et al.
Proceedings of the 20th European Symposium on Computer Aided Process Engineering. Elsevier, 2010. p. 241-246 (Computer Aided Chemical Engineering, Vol. 28).

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

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T1 - A systematic synthesis and design methodology to achieve process intensification in (bio) chemical processes

AU - Lutze, Philip

AU - Román-Martinez, Alicia

AU - Woodley, John

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N2 - Process intensification (PI) has the potential to improve existing processes or create new process options which are needed in order to produce products using more sustainable methods. PI creates an enormous number of process options. In order to manage the complexity of options in which a feasible and optimal process solution may exist, the application of process synthesis tools results in the development of a systematic methodology to implement PI. Starting from an analysis of existing processes, this methodology generates a set of feasible process options and reduces their number through a number of screening steps until from the remaining feasible options, the optimal is found. The application of this systematic methodology through a computer-aided framework is presented through a case study, the chemo-enzymatic synthesis of N-acetyl-D-neuraminic acid (Neu5Ac).

AB - Process intensification (PI) has the potential to improve existing processes or create new process options which are needed in order to produce products using more sustainable methods. PI creates an enormous number of process options. In order to manage the complexity of options in which a feasible and optimal process solution may exist, the application of process synthesis tools results in the development of a systematic methodology to implement PI. Starting from an analysis of existing processes, this methodology generates a set of feasible process options and reduces their number through a number of screening steps until from the remaining feasible options, the optimal is found. The application of this systematic methodology through a computer-aided framework is presented through a case study, the chemo-enzymatic synthesis of N-acetyl-D-neuraminic acid (Neu5Ac).

KW - Methodology

KW - Process synthesis

KW - Process intensification

KW - Biocatalysis

KW - N-acetylneuraminic acid (Neu5Ac)

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DO - 10.1016/S1570-7946(10)28041-0

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ER -

A systematic synthesis and design methodology to achieve process intensification in (bio) chemical processes

Abstract

Conference

Keywords

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