Abstract
Original language | English |
---|---|
Journal | Cell Reports |
Volume | 26 |
Issue number | 10 |
Pages (from-to) | 2622-2635 |
ISSN | 2211-1247 |
DOIs | |
Publication status | Published - 2019 |
Keywords
- cancer biomarkers
- pan-cancer
- protein secretion
- secretome
- systems biology
- unfolded protein response
Cite this
}
A Systematic Investigation of the Malignant Functions and Diagnostic Potential of the Cancer Secretome. / Robinson, Jonathan L.; Feizi, Amir; Uhlén, Mathias; Nielsen, Jens.
In: Cell Reports, Vol. 26, No. 10, 2019, p. 2622-2635.Research output: Contribution to journal › Journal article › Research › peer-review
TY - JOUR
T1 - A Systematic Investigation of the Malignant Functions and Diagnostic Potential of the Cancer Secretome
AU - Robinson, Jonathan L.
AU - Feizi, Amir
AU - Uhlén, Mathias
AU - Nielsen, Jens
PY - 2019
Y1 - 2019
N2 - The collection of proteins secreted from a cell-the secretome-is of particular interest in cancer pathophysiology due to its diagnostic potential and role in tumorigenesis. However, cancer secretome studies are often limited to one tissue or cancer type or focus on biomarker prediction without exploring the associated functions. We therefore conducted a pan-cancer analysis of secretome gene expression changes to identify candidate diagnostic biomarkers and to investigate the underlying biological function of these changes. Using transcriptomic data spanning 32 cancer types and 30 healthy tissues, we quantified the relative diagnostic potential of secretome proteins for each cancer. Furthermore, we offer a potential mechanism by which cancer cells relieve secretory pathway stress by decreasing the expression of tissue-specific genes, thereby facilitating the secretion of proteins promoting invasion and proliferation. These results provide a more systematic understanding of the cancer secretome, facilitating its use in diagnostics and its targeting for therapeutic development.
AB - The collection of proteins secreted from a cell-the secretome-is of particular interest in cancer pathophysiology due to its diagnostic potential and role in tumorigenesis. However, cancer secretome studies are often limited to one tissue or cancer type or focus on biomarker prediction without exploring the associated functions. We therefore conducted a pan-cancer analysis of secretome gene expression changes to identify candidate diagnostic biomarkers and to investigate the underlying biological function of these changes. Using transcriptomic data spanning 32 cancer types and 30 healthy tissues, we quantified the relative diagnostic potential of secretome proteins for each cancer. Furthermore, we offer a potential mechanism by which cancer cells relieve secretory pathway stress by decreasing the expression of tissue-specific genes, thereby facilitating the secretion of proteins promoting invasion and proliferation. These results provide a more systematic understanding of the cancer secretome, facilitating its use in diagnostics and its targeting for therapeutic development.
KW - cancer biomarkers
KW - pan-cancer
KW - protein secretion
KW - secretome
KW - systems biology
KW - unfolded protein response
U2 - 10.1016/j.celrep.2019.02.025
DO - 10.1016/j.celrep.2019.02.025
M3 - Journal article
VL - 26
SP - 2622
EP - 2635
JO - Cell Reports
JF - Cell Reports
SN - 2211-1247
IS - 10
ER -