A system for improved production titers in fermentations

Research output: PatentPatent – Annual report year: 2017

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A system for improved production titers in fermentations. / Rugbjerg, Peter (Inventor); Sarup-Lytzen, Kira (Inventor); Sommer, Morten Otto Alexander (Inventor).

IPC No.: C12P 1/ 04 A I. Patent No.: WO2017055360. Apr 06, 2017.

Research output: PatentPatent – Annual report year: 2017

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Rugbjerg P, Sarup-Lytzen K, Sommer MOA, inventors. 06-Apr-2017. A system for improved production titers in fermentations. IPC No. C12P 1/ 04 A I. Patent No. WO2017055360.

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Bibtex

@misc{9db80d82a2ff4df390b04006f2270d9c,
title = "A system for improved production titers in fermentations",
abstract = "The invention provides a genetically modified micro-organism for intracellular biosynthesis of a cellular metabolite, comprising a synthetic error correction system having a penalty gene, whose expression leads to arrested growth or cell death (e.g. a toxin gene) in combination with a survival gene, whose expression provides an antidote that restores cell viability and normal growth (e.g. a cognate antitoxin gene). Alternatively, the system has a survival gene, alone, whose expression is essential for growth (i.e. essential gene). The synthetic error correction system further comprises a biosensor, whose function is to induce expression of the survival gene which leads to cell growth, only, when the cell produces a pre-defined level of a given metabolite. The invention further encompasses: a method for producing the genetically modified micro-organism; a method for producing a cellular metabolite with the genetically modified micro-organism; and use of the genetically modified micro-organism for producing a cellular metabolite.",
author = "Peter Rugbjerg and Kira Sarup-Lytzen and Sommer, {Morten Otto Alexander}",
year = "2017",
month = "4",
day = "6",
language = "English",
type = "Patent",
note = "WO2017055360; C12P 1/ 04 A I",

}

RIS

TY - PAT

T1 - A system for improved production titers in fermentations

AU - Rugbjerg, Peter

AU - Sarup-Lytzen, Kira

AU - Sommer, Morten Otto Alexander

PY - 2017/4/6

Y1 - 2017/4/6

N2 - The invention provides a genetically modified micro-organism for intracellular biosynthesis of a cellular metabolite, comprising a synthetic error correction system having a penalty gene, whose expression leads to arrested growth or cell death (e.g. a toxin gene) in combination with a survival gene, whose expression provides an antidote that restores cell viability and normal growth (e.g. a cognate antitoxin gene). Alternatively, the system has a survival gene, alone, whose expression is essential for growth (i.e. essential gene). The synthetic error correction system further comprises a biosensor, whose function is to induce expression of the survival gene which leads to cell growth, only, when the cell produces a pre-defined level of a given metabolite. The invention further encompasses: a method for producing the genetically modified micro-organism; a method for producing a cellular metabolite with the genetically modified micro-organism; and use of the genetically modified micro-organism for producing a cellular metabolite.

AB - The invention provides a genetically modified micro-organism for intracellular biosynthesis of a cellular metabolite, comprising a synthetic error correction system having a penalty gene, whose expression leads to arrested growth or cell death (e.g. a toxin gene) in combination with a survival gene, whose expression provides an antidote that restores cell viability and normal growth (e.g. a cognate antitoxin gene). Alternatively, the system has a survival gene, alone, whose expression is essential for growth (i.e. essential gene). The synthetic error correction system further comprises a biosensor, whose function is to induce expression of the survival gene which leads to cell growth, only, when the cell produces a pre-defined level of a given metabolite. The invention further encompasses: a method for producing the genetically modified micro-organism; a method for producing a cellular metabolite with the genetically modified micro-organism; and use of the genetically modified micro-organism for producing a cellular metabolite.

M3 - Patent

M1 - WO2017055360

Y2 - 2017/04/06

ER -