A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins

Won Il Choi, Nazila Kamaly, Lorena Riol-Blanco, In-Hyun Lee, Jun Wu, Archana Swami, Cristian Vilos, Basit Yameen, Mikyung Yu, Jinjun Shi, Ira Tabas, Ulrich H. von Andrian, Sangyong Jon, Omid C. Farokhzad

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Abstract

Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.
Original languageEnglish
JournalNano Letters
Volume14
Issue number11
Pages (from-to)6449–6455
ISSN1530-6984
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Nanoparticles
  • Thermosponge
  • Solvent-free
  • Therapeutic proteins
  • Biologics

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