A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins

Won Il Choi; Nazila Kamaly; Lorena Riol-Blanco; In-Hyun Lee; Jun Wu; Archana Swami; Cristian Vilos; Basit Yameen; Mikyung Yu; Jinjun Shi; Ira Tabas; Ulrich H. von Andrian; Sangyong Jon; Omid C. Farokhzad

A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins

Won Il Choi, Nazila Kamaly, Lorena Riol-Blanco, In-Hyun Lee, Jun Wu, Archana Swami, Cristian Vilos, Basit Yameen, Mikyung Yu, Jinjun Shi, Ira Tabas, Ulrich H. von Andrian, Sangyong Jon, Omid C. Farokhzad

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Abstract

Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.

Original language	English
Journal	Nano Letters
Volume	14
Issue number	11
Pages (from-to)	6449–6455
ISSN	1530-6984
Publication status	Published - 2014
Externally published	Yes

Keywords

Nanoparticles
Thermosponge
Solvent-free
Therapeutic proteins
Biologics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{937ad914409d4b9b8d80377162ad9712,

title = "A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins",

abstract = "Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.",

keywords = "Nanoparticles, Thermosponge, Solvent-free, Therapeutic proteins, Biologics",

author = "Choi, {Won Il} and Nazila Kamaly and Lorena Riol-Blanco and In-Hyun Lee and Jun Wu and Archana Swami and Cristian Vilos and Basit Yameen and Mikyung Yu and Jinjun Shi and Ira Tabas and {von Andrian}, {Ulrich H.} and Sangyong Jon and Farokhzad, {Omid C.}",

year = "2014",

language = "English",

volume = "14",

pages = "6449–6455",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

number = "11",

}

TY - JOUR

T1 - A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins

AU - Choi, Won Il

AU - Kamaly, Nazila

AU - Riol-Blanco, Lorena

AU - Lee, In-Hyun

AU - Wu, Jun

AU - Swami, Archana

AU - Vilos, Cristian

AU - Yameen, Basit

AU - Yu, Mikyung

AU - Shi, Jinjun

AU - Tabas, Ira

AU - von Andrian, Ulrich H.

AU - Jon, Sangyong

AU - Farokhzad, Omid C.

PY - 2014

Y1 - 2014

N2 - Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.

AB - Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.

KW - Nanoparticles

KW - Thermosponge

KW - Solvent-free

KW - Therapeutic proteins

KW - Biologics

M3 - Journal article

SN - 1530-6984

VL - 14

SP - 6449

EP - 6455

JO - Nano Letters

JF - Nano Letters

IS - 11

ER -

A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins

Abstract

Keywords

UN SDGs

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