A Solvent-Free Base Liberation of a Tertiary Aminoalkyl Halide by Flow Chemistry

Michael Jønch Pedersen, Tommy Skovby, Michael J. Mealy, Kim Dam-Johansen, Søren Kiil

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A flow setup for base liberation of 3-(N,N-dimethylamino)propyl chloride hydrochloride and solvent-free separation of the resulting free base has been developed. Production in flow profits from an on-demand approach, useful for labile aminoalkyl halides. The requirement for obtaining a dry product has been fulfilled by the simple use of a saturated NaOH solution, followed by isolation of the liquid phases by gravimetric separation. The flow setup has an E factor reduction of nearly 50%, and a distillation step has been avoided. The method exemplifies how flow chemistry can be exploited to simplify, improve, and optimize manufacturing processes.
Original languageEnglish
JournalOrganic Process Research & Development
Volume20
Issue number12
Pages (from-to)2043-2049
ISSN1083-6160
DOIs
Publication statusPublished - 2016

Keywords

  • Acid−base reaction
  • Flow chemistry
  • Green chemistry

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