A solid support generator of the Auger electron emitter rhodium-103m from [103Pd]palladium

Andreas I. Jensen*, Fedor Zhuravlev, Gregory Severin, Charlotte Busk Magnus, Jesper Fonslet, Ulli Köster, Mikael Jensen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Auger electron therapy is an attractive modality for targeting microscopic tumors. Rhodium-103 m (103mRh, T½ = 56.1 min) is a promising Auger electron emitter that can be obtained as the decay product of palladium-103 (103Pd, T½ = 16.99 days). 103Pd was chelated in a lipophilic derivative of the 16aneS4 macrocycle and the complex was trapped on a C18 cartridge. Elution with dilute hydrochloric acid gave radiochemically pure 103mRh. We hypothesize this to be through a combination of the Szilard-Chalmers effect and transient ionization.
Original languageEnglish
Article number108985
JournalApplied Radiation and Isotopes
Volume156
Number of pages7
ISSN0969-8043
DOIs
Publication statusPublished - 2020

Keywords

  • Auger radiotherapy
  • Radionuclide generator
  • Rhodium-103m
  • Palladium-103
  • 16aneS4

Cite this

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title = "A solid support generator of the Auger electron emitter rhodium-103m from [103Pd]palladium",
abstract = "Auger electron therapy is an attractive modality for targeting microscopic tumors. Rhodium-103 m (103mRh, T½ = 56.1 min) is a promising Auger electron emitter that can be obtained as the decay product of palladium-103 (103Pd, T½ = 16.99 days). 103Pd was chelated in a lipophilic derivative of the 16aneS4 macrocycle and the complex was trapped on a C18 cartridge. Elution with dilute hydrochloric acid gave radiochemically pure 103mRh. We hypothesize this to be through a combination of the Szilard-Chalmers effect and transient ionization.",
keywords = "Auger radiotherapy, Radionuclide generator, Rhodium-103m, Palladium-103, 16aneS4",
author = "Jensen, {Andreas I.} and Fedor Zhuravlev and Gregory Severin and Magnus, {Charlotte Busk} and Jesper Fonslet and Ulli K{\"o}ster and Mikael Jensen",
year = "2020",
doi = "10.1016/j.apradiso.2019.108985",
language = "English",
volume = "156",
journal = "Applied Radiation and Isotopes",
issn = "0969-8043",
publisher = "Pergamon Press",

}

A solid support generator of the Auger electron emitter rhodium-103m from [103Pd]palladium. / Jensen, Andreas I.; Zhuravlev, Fedor; Severin, Gregory; Magnus, Charlotte Busk; Fonslet, Jesper; Köster, Ulli; Jensen, Mikael.

In: Applied Radiation and Isotopes, Vol. 156, 108985, 2020.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - A solid support generator of the Auger electron emitter rhodium-103m from [103Pd]palladium

AU - Jensen, Andreas I.

AU - Zhuravlev, Fedor

AU - Severin, Gregory

AU - Magnus, Charlotte Busk

AU - Fonslet, Jesper

AU - Köster, Ulli

AU - Jensen, Mikael

PY - 2020

Y1 - 2020

N2 - Auger electron therapy is an attractive modality for targeting microscopic tumors. Rhodium-103 m (103mRh, T½ = 56.1 min) is a promising Auger electron emitter that can be obtained as the decay product of palladium-103 (103Pd, T½ = 16.99 days). 103Pd was chelated in a lipophilic derivative of the 16aneS4 macrocycle and the complex was trapped on a C18 cartridge. Elution with dilute hydrochloric acid gave radiochemically pure 103mRh. We hypothesize this to be through a combination of the Szilard-Chalmers effect and transient ionization.

AB - Auger electron therapy is an attractive modality for targeting microscopic tumors. Rhodium-103 m (103mRh, T½ = 56.1 min) is a promising Auger electron emitter that can be obtained as the decay product of palladium-103 (103Pd, T½ = 16.99 days). 103Pd was chelated in a lipophilic derivative of the 16aneS4 macrocycle and the complex was trapped on a C18 cartridge. Elution with dilute hydrochloric acid gave radiochemically pure 103mRh. We hypothesize this to be through a combination of the Szilard-Chalmers effect and transient ionization.

KW - Auger radiotherapy

KW - Radionuclide generator

KW - Rhodium-103m

KW - Palladium-103

KW - 16aneS4

U2 - 10.1016/j.apradiso.2019.108985

DO - 10.1016/j.apradiso.2019.108985

M3 - Journal article

VL - 156

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

SN - 0969-8043

M1 - 108985

ER -