A solid support generator of the Auger electron emitter rhodium-103m from [103Pd]palladium

Andreas I. Jensen*, Fedor Zhuravlev, Gregory Severin, Charlotte Busk Magnus, Jesper Fonslet, Ulli Köster, Mikael Jensen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Auger electron therapy is an attractive modality for targeting microscopic tumors. Rhodium-103 m (103mRh, T½ = 56.1 min) is a promising Auger electron emitter that can be obtained as the decay product of palladium-103 (103Pd, T½ = 16.99 days). 103Pd was chelated in a lipophilic derivative of the 16aneS4 macrocycle and the complex was trapped on a C18 cartridge. Elution with dilute hydrochloric acid gave radiochemically pure 103mRh. We hypothesize this to be through a combination of the Szilard-Chalmers effect and transient ionization.
Original languageEnglish
Article number108985
JournalApplied Radiation and Isotopes
Volume156
Number of pages7
ISSN0969-8043
DOIs
Publication statusPublished - 2020

Keywords

  • Auger radiotherapy
  • Radionuclide generator
  • Rhodium-103m
  • Palladium-103
  • 16aneS4

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