A Smart Mobile Lab-on-Chip-Based Medical Diagnostics System Architecture Designed For Evolvability

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Abstract

Unprecedented knowledge levels in life sciences along with technological advances in micro- and nanotechnologies and microfluidics have recently conditioned the advent of Lab-on-Chip (LoC) devices for In-Vitro Medical Testing
(IVMT). Combined with smart-mobile technologies, LoCs are pervasively giving rise to opportunities to better diagnose disease, predict and monitor personalised treatment efficacy, or provide healthcare decision-making support at the Point-of-Care (PoC). Although made increasingly available to the consumer market, the adoption of LoC-based PoC In-Vitro Medical Testing (IVMT) systems is still in its infancy. This attrition partly pertains to the intricacy of designing and developing complex systems, destined to be used sporadically, in a fast-pace evolving technological paradigm. System evolvability is therefore key in the design process and constitutes the main motivation for this work.
We introduce a smart-mobile and LoC-based system architecture designed for evolvability. By propagating LoC programmability, instrumentation, and control tools to the highlevel abstraction smart-mobile software layer, our architecture
facilitates the realisation of new use-cases and the accommodation for incremental LoC-technology developments. We demonstrate these features with an implementation allowing the interfacing of LoCs embedding current- or impedance-based biosensors such as Silicon Nanowire Field Effect Transistors
(SiNW-FETs) or electrochemical transducers. Structural modifications of these LoCs or changes in their specific operation may be addressed by the sole reengineering of the mobilesoftware layer, minimising system upgrade development and validation costs and efforts.
Original languageEnglish
Title of host publicationProceedings of the Euromicro Conference on Digital System Design 2015
PublisherIEEE
Publication date2015
Pages390-398
ISBN (Print)9781467380355
DOIs
Publication statusPublished - 2015
Event Euromicro Conference on Digital System Design 2015 - Funchal, Madeira, Portugal
Duration: 26 Aug 201528 Aug 2015

Conference

Conference Euromicro Conference on Digital System Design 2015
CountryPortugal
CityFunchal, Madeira
Period26/08/201528/08/2015

Keywords

  • Lab-on-Chip
  • Smartphone
  • Point-of-care
  • In-vitro medical diagnostics
  • System evolvability
  • System architecting

Cite this

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title = "A Smart Mobile Lab-on-Chip-Based Medical Diagnostics System Architecture Designed For Evolvability",
abstract = "Unprecedented knowledge levels in life sciences along with technological advances in micro- and nanotechnologies and microfluidics have recently conditioned the advent of Lab-on-Chip (LoC) devices for In-Vitro Medical Testing(IVMT). Combined with smart-mobile technologies, LoCs are pervasively giving rise to opportunities to better diagnose disease, predict and monitor personalised treatment efficacy, or provide healthcare decision-making support at the Point-of-Care (PoC). Although made increasingly available to the consumer market, the adoption of LoC-based PoC In-Vitro Medical Testing (IVMT) systems is still in its infancy. This attrition partly pertains to the intricacy of designing and developing complex systems, destined to be used sporadically, in a fast-pace evolving technological paradigm. System evolvability is therefore key in the design process and constitutes the main motivation for this work.We introduce a smart-mobile and LoC-based system architecture designed for evolvability. By propagating LoC programmability, instrumentation, and control tools to the highlevel abstraction smart-mobile software layer, our architecturefacilitates the realisation of new use-cases and the accommodation for incremental LoC-technology developments. We demonstrate these features with an implementation allowing the interfacing of LoCs embedding current- or impedance-based biosensors such as Silicon Nanowire Field Effect Transistors(SiNW-FETs) or electrochemical transducers. Structural modifications of these LoCs or changes in their specific operation may be addressed by the sole reengineering of the mobilesoftware layer, minimising system upgrade development and validation costs and efforts.",
keywords = "Lab-on-Chip, Smartphone, Point-of-care, In-vitro medical diagnostics, System evolvability, System architecting",
author = "Fran{\cc}ois Patou and Maria Dimaki and Svendsen, {Winnie Edith} and Claus Kj{\ae}rgaard and Jan Madsen",
year = "2015",
doi = "10.1109/DSD.2015.11",
language = "English",
isbn = "9781467380355",
pages = "390--398",
booktitle = "Proceedings of the Euromicro Conference on Digital System Design 2015",
publisher = "IEEE",
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}

Patou, F, Dimaki, M, Svendsen, WE, Kjærgaard, C & Madsen, J 2015, A Smart Mobile Lab-on-Chip-Based Medical Diagnostics System Architecture Designed For Evolvability. in Proceedings of the Euromicro Conference on Digital System Design 2015. IEEE, pp. 390-398, Euromicro Conference on Digital System Design 2015, Funchal, Madeira, Portugal, 26/08/2015. https://doi.org/10.1109/DSD.2015.11

A Smart Mobile Lab-on-Chip-Based Medical Diagnostics System Architecture Designed For Evolvability. / Patou, François; Dimaki, Maria; Svendsen, Winnie Edith; Kjærgaard, Claus; Madsen, Jan.

Proceedings of the Euromicro Conference on Digital System Design 2015. IEEE, 2015. p. 390-398.

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

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AB - Unprecedented knowledge levels in life sciences along with technological advances in micro- and nanotechnologies and microfluidics have recently conditioned the advent of Lab-on-Chip (LoC) devices for In-Vitro Medical Testing(IVMT). Combined with smart-mobile technologies, LoCs are pervasively giving rise to opportunities to better diagnose disease, predict and monitor personalised treatment efficacy, or provide healthcare decision-making support at the Point-of-Care (PoC). Although made increasingly available to the consumer market, the adoption of LoC-based PoC In-Vitro Medical Testing (IVMT) systems is still in its infancy. This attrition partly pertains to the intricacy of designing and developing complex systems, destined to be used sporadically, in a fast-pace evolving technological paradigm. System evolvability is therefore key in the design process and constitutes the main motivation for this work.We introduce a smart-mobile and LoC-based system architecture designed for evolvability. By propagating LoC programmability, instrumentation, and control tools to the highlevel abstraction smart-mobile software layer, our architecturefacilitates the realisation of new use-cases and the accommodation for incremental LoC-technology developments. We demonstrate these features with an implementation allowing the interfacing of LoCs embedding current- or impedance-based biosensors such as Silicon Nanowire Field Effect Transistors(SiNW-FETs) or electrochemical transducers. Structural modifications of these LoCs or changes in their specific operation may be addressed by the sole reengineering of the mobilesoftware layer, minimising system upgrade development and validation costs and efforts.

KW - Lab-on-Chip

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KW - System architecting

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