@inproceedings{bdf7696ef8df4820a4c859914adee322,
title = "A shortcut approach for decision-making and operational analysis of an integrated end-to-end continuous pharmaceutical process",
abstract = "In this work, a plant-wide model-based shortcut approach for decision-making and operational analysis of integrated end-to-end continuous pharmaceutical processes is developed and tested. The proposed hierarchical approach is implemented through a computer-aided framework. Using concepts of Layer of Protection Analysis (LOPA) combined with Net Present Value (NPV) are embedded in the framework from a modelbased point of view to comprehensively assess the overall benefits of a specific operational point. This in turn can be used to make an informed decision between competing operation alternatives. The application of the framework is demonstrated through a validated dynamic process model of an integrated end-to-end continuous pharmaceutical pilot plant. In this application, the implications of changing process operations from single pass operation to raw material recycling have been investigated.",
keywords = "Decision-making, Layer of protection analysis (LOPA), NPV",
author = "Mansouri, \{Seyed Soheil\} and Udugama, \{Isuru A.\} and Huusom, \{Jakob Kj{\o}bsted\} and Gernaey, \{Krist V.\} and Brahim Benyahia",
year = "2018",
doi = "10.1016/B978-0-444-64241-7.50346-3",
language = "English",
volume = "44",
series = "Computer Aided Chemical Engineering",
publisher = "Elsevier",
pages = "2107--2112",
editor = "Eden, \{Mario R.\} and Ierapetritou, \{Marianthi G. \} and Towler, \{Gavin P. \}",
booktitle = "Proceedings of the 13th International Symposium on Process Systems Engineering – PSE 2018",
address = "United Kingdom",
note = "13th International Symposium on Process Systems Engineering (PSE 2018) ; Conference date: 01-07-2018 Through 05-07-2018",
}