A serum biomarker reflecting collagen type I degradation (C1M) is an independent risk factor for acute myocardial infarction in postmenopausal women: results from the PERF study

D.M. Bertelsen, Signe Holm Nielsen, J.S. Neergaard, Morten Asser Karsdal, H.B. Nielsen

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Abstract

Cardiovascular disease (CVD) is the leading cause of death in postmenopausal women, and symptoms of ischemic heart disease (IHD) and acute myocardial infarction (AMI) are often overlooked. With the loss of estrogen production collagen stability is affected with potential of an increased risk of unstable plaques in coronary vessels. Collagen type I, a major component of the cardiac extracellular matrix (ECM), is cleaved by matrix metalloproteinases (MMPs) and known to be active remodeled in CVD.
Original languageEnglish
Article numberP3449
JournalEuropean Heart Journal
Volume38
Issue numberSuppl. 1
Pages (from-to)722
ISSN0195-668X
DOIs
Publication statusPublished - 2017
EventESC Congress 2017: 40 Years of PCI - Barcelona, Spain
Duration: 26 Aug 201730 Aug 2017
https://www.escardio.org/Congresses-%26-Events/ESC-Congress

Conference

ConferenceESC Congress 2017
CountrySpain
CityBarcelona
Period26/08/201730/08/2017
Internet address

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