A serum biomarker reflecting collagen type I degradation (C1M) is an independent risk factor for acute myocardial infarction in postmenopausal women: results from the PERF study

D.M. Bertelsen; Signe Holm Nielsen; J.S. Neergaard; Morten Asser Karsdal; H.B. Nielsen

doi:10.1093/eurheartj/ehx504.P3449

A serum biomarker reflecting collagen type I degradation (C1M) is an independent risk factor for acute myocardial infarction in postmenopausal women: results from the PERF study

D.M. Bertelsen, Signe Holm Nielsen, J.S. Neergaard, Morten Asser Karsdal, H.B. Nielsen

Department of Biotechnology and Biomedicine

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

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Abstract

Cardiovascular disease (CVD) is the leading cause of death in postmenopausal women, and symptoms of ischemic heart disease (IHD) and acute myocardial infarction (AMI) are often overlooked. With the loss of estrogen production collagen stability is affected with potential of an increased risk of unstable plaques in coronary vessels. Collagen type I, a major component of the cardiac extracellular matrix (ECM), is cleaved by matrix metalloproteinases (MMPs) and known to be active remodeled in CVD.

Original language	English
Article number	P3449
Journal	European Heart Journal
Volume	38
Issue number	Suppl. 1
Pages (from-to)	722
ISSN	0195-668X
DOIs	https://doi.org/10.1093/eurheartj/ehx504.P3449
Publication status	Published - 2017
Event	ESC Congress 2017: 40 Years of PCI - Barcelona, Spain Duration: 26 Aug 2017 → 30 Aug 2017 https://www.escardio.org/Congresses-%26-Events/ESC-Congress

Conference

Conference	ESC Congress 2017
Country/Territory	Spain
City	Barcelona
Period	26/08/2017 → 30/08/2017
Internet address	https://www.escardio.org/Congresses-%26-Events/ESC-Congress

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Bertelsen, D. M., Nielsen, S. H., Neergaard, J. S., Karsdal, M. A., & Nielsen, H. B. (2017). A serum biomarker reflecting collagen type I degradation (C1M) is an independent risk factor for acute myocardial infarction in postmenopausal women: results from the PERF study. European Heart Journal, 38(Suppl. 1), 722. Article P3449. https://doi.org/10.1093/eurheartj/ehx504.P3449

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abstract = "Cardiovascular disease (CVD) is the leading cause of death in postmenopausal women, and symptoms of ischemic heart disease (IHD) and acute myocardial infarction (AMI) are often overlooked. With the loss of estrogen production collagen stability is affected with potential of an increased risk of unstable plaques in coronary vessels. Collagen type I, a major component of the cardiac extracellular matrix (ECM), is cleaved by matrix metalloproteinases (MMPs) and known to be active remodeled in CVD.",

author = "D.M. Bertelsen and Nielsen, {Signe Holm} and J.S. Neergaard and Karsdal, {Morten Asser} and H.B. Nielsen",

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doi = "10.1093/eurheartj/ehx504.P3449",

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A serum biomarker reflecting collagen type I degradation (C1M) is an independent risk factor for acute myocardial infarction in postmenopausal women: results from the PERF study. / Bertelsen, D.M.; Nielsen, Signe Holm; Neergaard, J.S. et al.
In: European Heart Journal, Vol. 38, No. Suppl. 1, P3449, 2017, p. 722.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

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A serum biomarker reflecting collagen type I degradation (C1M) is an independent risk factor for acute myocardial infarction in postmenopausal women: results from the PERF study

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