A seasonal variation of calcitropic hormones, bone turnover and bone mineral density in early and mid-puberty girls - a cross-sectional study

H.T. Viljakainen, A. Palssa, M. Karkkainen, Jette Jakobsen, K.D. Cashman, C. Mølgaard, C. Lamberg-Allardt

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The importance of the seasonal variation of calcitropic hormones to growing skeleton has not been established. We studied whether there exists a seasonal variation in calcitropic hormones, bone mineral density (BMD) and bone remodelling markers in early puberty girls. One hundred and ninety-six girls, mean age 11 center dot 4 (sd 0 center dot 4) years, in Tanner stage 2 (early puberty) and 3 (mid-puberty) were studied during September to March. The BMD was measured from the lumbar vertebrae and the left femur by dual-energy X-ray absoptiometry. Their serum 25-hydroxyvitamin D (S-25-OHD), serum intact parathyroid hormone (S-iPTH), serum osteocalcin, urinary pyridinoline and urinary deoxypyridinoline were analysed from fasting samples. The concentration of S-25-OHD and serum osteocalcin differed among months (P <0 center dot 01), reflecting a seasonal variation. The parathyroid hormone correlated negatively with S-25-OHD (r -0 center dot 325, P <0 center dot 001). Moreover, the BMD in the femur (P=0 center dot 047) and to a lesser extent in vertebrae (P=0 center dot 057) differed between months in early puberty girls but this was not seen in mid-puberty. Seasonal variation in S-25-OHD and bone remodelling markers accompanied by negative correlation between S-25-OHD and S-iPTH was seen in this cross-sectional study of adolescent girls. In addition, the seasonal rhythm contributed 7 center dot 0-7 center dot 6 % difference in the BMD of lumbar vertebrae and left femur in early puberty girls. This variation should be avoided since it could hamper peak bone mass attainment.
Original languageEnglish
JournalBritish Journal of Nutrition
Volume96
Issue number1
Pages (from-to)124-130
ISSN0007-1145
Publication statusPublished - 2006

Keywords

  • adolescent girls
  • bone remodelling markers
  • seasonal variation
  • 25-hydroxyvitamin D
  • bone mineral density
  • cross-sectional study

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