A sample holder for in-house X-ray powder diffraction studies of protein powders

Christian Grundahl Frankær, Pernille Harris, Kenny Ståhl

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Abstract

A sample holder for handling samples of protein for in-house X-ray powder diffraction (XRPD) analysis has been made and tested on lysozyme. The use of an integrated pinhole reduced the background, and good signal-to-noise ratios were obtained from only 7 l of sample, corresponding to approximately 2-3 mg of dry protein. The sample holder is further adaptable to X-ray absorption spectroscopy (XAS) measurements. Both XRPD and XAS at the Zn K-edge were tested with hexameric Zn insulin.
Original languageEnglish
JournalJournal of Applied Crystallography
Volume44
Issue number6
Pages (from-to)1288-1290
ISSN0021-8898
DOIs
Publication statusPublished - 2011

Bibliographical note

© 2011 International Union of Crystallography

Keywords

  • Lysozyme
  • In-house powder diffraction
  • X-ray absorption spectroscopy
  • Sample holders
  • Insulin

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