A Robust Process Analytical Technology (PAT) System Design for Crystallization Processes

Noor Asma Fazli Bin Abdul Samad, Gürkan Sin, Krist Gernaey, Rafiqul Gani

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

A generic computer-aided framework for systematic design of a process monitoring and control system for crystallization processes has been developed to study various aspects of crystallization operations. The design framework contains a generic multidimensional modelling framework, a tool for generation of the supersaturation setpoint for a supersaturation controller, a tool for design of a process monitoring and control system (also called Process Analytical Technology (PAT) system) as well as a tool for performing uncertainty and sensitivity analysis of the PAT system design. The uncertainty analysis is important in order to produce an estimate of the risk of not achieving the desired product quality with its corresponding target crystal properties.
Application of the framework is highlighted through a case study involving the design of a robust PAT system for a potassium dichromate crystallization process to achieve the target crystal size distribution (CSD) in the presence of parametric uncertainties.
Original languageEnglish
Title of host publicationProceedings of 20th International Workshop on Industrial Crystallization (BIWIC2013)
Number of pages8
PublisherUniversity of Southern Denmark
Publication date2013
Publication statusPublished - 2013
EventBIWIC 2013: 20th International Workshop on Industrial Crystallization - Odense, Denmark
Duration: 18 Sep 201320 Sep 2013

Conference

ConferenceBIWIC 2013
CountryDenmark
CityOdense
Period18/09/201320/09/2013

Cite this

Abdul Samad, N. A. F. B., Sin, G., Gernaey, K., & Gani, R. (2013). A Robust Process Analytical Technology (PAT) System Design for Crystallization Processes. In Proceedings of 20th International Workshop on Industrial Crystallization (BIWIC2013) University of Southern Denmark.