A Review on Tumor-Treating Fields (TTFields): Clinical Implications Inferred from Computational Modeling

Cornelia Wenger*, Pedro C. Miranda, Ricardo Salvador, Axel Thielscher, Zeev Bomzon, Moshe Giladi, MacIej M. Mrugala, Anders R. Korshoej

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

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Abstract

Tumor-treating fields (TTFields) are a cancer treatment modality that uses alternating electric fields of intermediate frequency (∼100-500 kHz) and low intensity (1-3 V/cm) to disrupt cell division. TTFields are delivered by transducer arrays placed on the skin close to the tumor and act regionally and noninvasively to inhibit tumor growth. TTFields therapy is U.S. Food and Drug Administration approved for the treatment of glioblastoma multiforme, the most common and aggressive primary human brain cancer. Clinical trials testing the safety and efficacy of TTFields for other solid tumor types are underway. The objective of this paper is to review computational approaches used to characterize TTFields. The review covers studies of the macroscopic spatial distribution of TTFields generated in the human head, and of the microscopic field distribution in tumor cells. In addition, preclinical and clinical findings related to TTFields and principles of its operation are summarized. Particular emphasis is put on outlining the potential clinical value inferred from computational modeling.

Original languageEnglish
JournalI E E E Reviews in Biomedical Engineering
Volume11
Pages (from-to)195-207
ISSN1937-3333
DOIs
Publication statusPublished - 12 Feb 2018

Keywords

  • Cancer treatment
  • Computational modeling and simulation
  • Finite element models
  • Tumor-treating fields (TTFields)

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