A remote but significant sequence homology between glycoside hydrolase clan GH-H and glycoside hydrolase family GH 31

S. Janecek, Birte Svensson, E.A. MacGregor

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Although both the α-amylase super-family, i.e. the glycoside hydrolase (GH) clan GH-H (the GH families 13, 70 and 77), and family GH31 share some characteristics, their different catalytic machinery prevents classification of GH31 in clan GH-H. A significant but remote evolutionary relatedness is, however, proposed for clan GH-H with GH31. A sequence alignment, based on the idea that residues equivalent in the primordial catalytic GH-H/GH31 (β/α)8-barrel may not be found in the present-day GH-H and GH31 structures at strictly equivalent positions, shows remote sequence homologies covering β3, β4, β7 and β8 of the GH-H and GH31 (β/α)8-barrels. Structure comparison of GH13 α-amylase and GH31 α-xylosidase guided alignment of GH-H and GH31 members for construction of evolutionary trees. The closest sequence relationship displayed by GH31 is to GH77 of clan GH-H.
    Original languageEnglish
    JournalF E B S Letters
    Volume581
    Issue number7
    Pages (from-to)1261-1268
    ISSN0014-5793
    DOIs
    Publication statusPublished - 2007

    Cite this

    @article{2874e6abac7742998f324d4bde4a4f8c,
    title = "A remote but significant sequence homology between glycoside hydrolase clan GH-H and glycoside hydrolase family GH 31",
    abstract = "Although both the α-amylase super-family, i.e. the glycoside hydrolase (GH) clan GH-H (the GH families 13, 70 and 77), and family GH31 share some characteristics, their different catalytic machinery prevents classification of GH31 in clan GH-H. A significant but remote evolutionary relatedness is, however, proposed for clan GH-H with GH31. A sequence alignment, based on the idea that residues equivalent in the primordial catalytic GH-H/GH31 (β/α)8-barrel may not be found in the present-day GH-H and GH31 structures at strictly equivalent positions, shows remote sequence homologies covering β3, β4, β7 and β8 of the GH-H and GH31 (β/α)8-barrels. Structure comparison of GH13 α-amylase and GH31 α-xylosidase guided alignment of GH-H and GH31 members for construction of evolutionary trees. The closest sequence relationship displayed by GH31 is to GH77 of clan GH-H.",
    author = "S. Janecek and Birte Svensson and E.A. MacGregor",
    year = "2007",
    doi = "10.1016/j.febslet.2007.02.036",
    language = "English",
    volume = "581",
    pages = "1261--1268",
    journal = "F E B S Letters",
    issn = "0014-5793",
    publisher = "JohnWiley & Sons Ltd.",
    number = "7",

    }

    A remote but significant sequence homology between glycoside hydrolase clan GH-H and glycoside hydrolase family GH 31. / Janecek, S.; Svensson, Birte; MacGregor, E.A.

    In: F E B S Letters, Vol. 581, No. 7, 2007, p. 1261-1268.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - A remote but significant sequence homology between glycoside hydrolase clan GH-H and glycoside hydrolase family GH 31

    AU - Janecek, S.

    AU - Svensson, Birte

    AU - MacGregor, E.A.

    PY - 2007

    Y1 - 2007

    N2 - Although both the α-amylase super-family, i.e. the glycoside hydrolase (GH) clan GH-H (the GH families 13, 70 and 77), and family GH31 share some characteristics, their different catalytic machinery prevents classification of GH31 in clan GH-H. A significant but remote evolutionary relatedness is, however, proposed for clan GH-H with GH31. A sequence alignment, based on the idea that residues equivalent in the primordial catalytic GH-H/GH31 (β/α)8-barrel may not be found in the present-day GH-H and GH31 structures at strictly equivalent positions, shows remote sequence homologies covering β3, β4, β7 and β8 of the GH-H and GH31 (β/α)8-barrels. Structure comparison of GH13 α-amylase and GH31 α-xylosidase guided alignment of GH-H and GH31 members for construction of evolutionary trees. The closest sequence relationship displayed by GH31 is to GH77 of clan GH-H.

    AB - Although both the α-amylase super-family, i.e. the glycoside hydrolase (GH) clan GH-H (the GH families 13, 70 and 77), and family GH31 share some characteristics, their different catalytic machinery prevents classification of GH31 in clan GH-H. A significant but remote evolutionary relatedness is, however, proposed for clan GH-H with GH31. A sequence alignment, based on the idea that residues equivalent in the primordial catalytic GH-H/GH31 (β/α)8-barrel may not be found in the present-day GH-H and GH31 structures at strictly equivalent positions, shows remote sequence homologies covering β3, β4, β7 and β8 of the GH-H and GH31 (β/α)8-barrels. Structure comparison of GH13 α-amylase and GH31 α-xylosidase guided alignment of GH-H and GH31 members for construction of evolutionary trees. The closest sequence relationship displayed by GH31 is to GH77 of clan GH-H.

    U2 - 10.1016/j.febslet.2007.02.036

    DO - 10.1016/j.febslet.2007.02.036

    M3 - Journal article

    VL - 581

    SP - 1261

    EP - 1268

    JO - F E B S Letters

    JF - F E B S Letters

    SN - 0014-5793

    IS - 7

    ER -