Herein we describe a novel rational approach to the design of a ω-transaminase process such that it will fulfill criteria necessary for industrial use. By first determining the fundamental properties of the reaction system, it is possible to suggest appropriate process strategies that may be used to overcome any unfavorable parameters. The ω-transaminase is used as a model system because it is an important enzyme class and developing a systematic methodology would have significant value.
|Publication status||Published - 2013|
|Event||1st International Symposium on Transaminase Biocatalysis - KTH, Stockholm, Sweden|
Duration: 28 Feb 2013 → 1 Mar 2013
|Conference||1st International Symposium on Transaminase Biocatalysis|
|Period||28/02/2013 → 01/03/2013|
T. Gundersen, M., Lloyd, R., Tufvesson, P., & Woodley, J. (2013). A rational approach for ω-transaminase-catalyzed process design: Synthesis of p-Br-1-phenylethylamine. Poster session presented at 1st International Symposium on Transaminase Biocatalysis, Stockholm, Sweden.