A rational approach for ω-transaminase-catalyzed process design: Synthesis of p-Br-1-phenylethylamine

Maria T. Gundersen; Richard Lloyd; Pär Tufvesson; John Woodley

A rational approach for ω-transaminase-catalyzed process design: Synthesis of p-Br-1-phenylethylamine

Maria T. Gundersen, Richard Lloyd, Pär Tufvesson, John Woodley

Department of Chemical and Biochemical Engineering

Dr. Reddy's Laboratories Ltd.

Research output: Contribution to conference › Poster › Research › peer-review

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Abstract

Herein we describe a novel rational approach to the design of a ω-transaminase process such that it will fulfill criteria necessary for industrial use. By first determining the fundamental properties of the reaction system, it is possible to suggest appropriate process strategies that may be used to overcome any unfavorable parameters. The ω-transaminase is used as a model system because it is an important enzyme class and developing a systematic methodology would have significant value.

Original language	English
Publication date	2013
Publication status	Published - 2013
Event	1st International Symposium on Transaminase Biocatalysis - KTH, Stockholm, Sweden Duration: 28 Feb 2013 → 1 Mar 2013

Conference

Conference	1st International Symposium on Transaminase Biocatalysis
Location	KTH
Country/Territory	Sweden
City	Stockholm
Period	28/02/2013 → 01/03/2013

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A rational approach for transaminase catalyzed process design synthesis of p Br 1 phenylethylamine Maria T GundersenFinal published version, 879 KB

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title = "A rational approach for ω-transaminase-catalyzed process design: Synthesis of p-Br-1-phenylethylamine",

abstract = "Herein we describe a novel rational approach to the design of a ω-transaminase process such that it will fulfill criteria necessary for industrial use. By first determining the fundamental properties of the reaction system, it is possible to suggest appropriate process strategies that may be used to overcome any unfavorable parameters. The ω-transaminase is used as a model system because it is an important enzyme class and developing a systematic methodology would have significant value.",

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T1 - A rational approach for ω-transaminase-catalyzed process design

T2 - 1st International Symposium on Transaminase Biocatalysis

AU - T. Gundersen, Maria

AU - Lloyd, Richard

AU - Tufvesson, Pär

AU - Woodley, John

PY - 2013

Y1 - 2013

N2 - Herein we describe a novel rational approach to the design of a ω-transaminase process such that it will fulfill criteria necessary for industrial use. By first determining the fundamental properties of the reaction system, it is possible to suggest appropriate process strategies that may be used to overcome any unfavorable parameters. The ω-transaminase is used as a model system because it is an important enzyme class and developing a systematic methodology would have significant value.

AB - Herein we describe a novel rational approach to the design of a ω-transaminase process such that it will fulfill criteria necessary for industrial use. By first determining the fundamental properties of the reaction system, it is possible to suggest appropriate process strategies that may be used to overcome any unfavorable parameters. The ω-transaminase is used as a model system because it is an important enzyme class and developing a systematic methodology would have significant value.

M3 - Poster

Y2 - 28 February 2013 through 1 March 2013

ER -

A rational approach for ω-transaminase-catalyzed process design: Synthesis of p-Br-1-phenylethylamine

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