A rational approach for ω-transaminase-catalyzed process design: Synthesis of p-Br-1-phenylethylamine

Maria T. Gundersen, Richard Lloyd, Pär Tufvesson, John Woodley

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Abstract

Herein we describe a novel rational approach to the design of a ω-transaminase process such that it will fulfill criteria necessary for industrial use. By first determining the fundamental properties of the reaction system, it is possible to suggest appropriate process strategies that may be used to overcome any unfavorable parameters. The ω-transaminase is used as a model system because it is an important enzyme class and developing a systematic methodology would have significant value.
Original languageEnglish
Publication date2013
Publication statusPublished - 2013
Event1st International Symposium on Transaminase Biocatalysis - KTH, Stockholm, Sweden
Duration: 28 Feb 20131 Mar 2013

Conference

Conference1st International Symposium on Transaminase Biocatalysis
LocationKTH
CountrySweden
CityStockholm
Period28/02/201301/03/2013

Cite this

T. Gundersen, M., Lloyd, R., Tufvesson, P., & Woodley, J. (2013). A rational approach for ω-transaminase-catalyzed process design: Synthesis of p-Br-1-phenylethylamine. Poster session presented at 1st International Symposium on Transaminase Biocatalysis, Stockholm, Sweden.