A prospective observational longitudinal study of new-onset seizures and newly diagnosed epilepsy in dogs

N Fredsø, Nils Toft, A. Sabers, M. Berendt

    Research output: Contribution to journalJournal articleResearchpeer-review

    310 Downloads (Pure)

    Abstract

    Seizures are common in dogs and can be caused by non-epileptic conditions or epilepsy. The clinical course of newly diagnosed epilepsy is sparsely documented. The objective of this study was to prospectively investigate causes for seizures (epileptic and non-epileptic) in a cohort of dogs with new-onset untreated seizures, and for those dogs with newly diagnosed epilepsy to investigate epilepsy type, seizure type and the course of disease over time, including the risk of seizure recurrence. Untreated client-owned dogs experiencing new-onset seizures were prospectively enrolled in a longitudinal observational study including clinical investigations and long-term monitoring at the Copenhagen University Hospital for Companion Animals. A baseline clinical assessment was followed by investigator/owner contact every eight weeks from inclusion to death or end of study. Inclusion of dogs was conducted from November 2010 to September 2012, and the study terminated in June 2014. One hundred and six dogs were included in the study. Seventy-nine dogs (74.5%) were diagnosed with epilepsy: 61 dogs (77.2%) with idiopathic epilepsy, 13 dogs (16.5%) with structural epilepsy and five dogs (6.3%) with suspected structural epilepsy. A non-epileptic cause for seizures was identified in 13 dogs and suspected in 10 dogs. Four dogs in which no cause for seizures was identified experienced only one seizure during the study. In dogs with idiopathic epilepsy 60% had their second epileptic seizure within three months of seizure onset. Twenty-six dogs with idiopathic epilepsy (43%) completed the study without receiving antiepileptic treatment. The natural course of idiopathic epilepsy (uninfluenced by drugs) was illustrated by highly individual and fluctuating seizure patterns, including long periods of remission. Cluster seizures motivated early treatment. In a few dogs with a high seizure frequency owners declined treatment against the investigators advice. Epilepsy is the most likely diagnosis in dogs presenting with new-onset seizures. The course of idiopathic epilepsy is highly individual and might not necessarily require long-term treatment. This must be considered when advising owners about what to expect with regard to treatment and prognosis.
    Original languageEnglish
    Article number54
    JournalB M C Veterinary Research
    Volume13
    Issue number1
    Number of pages11
    ISSN1746-6148
    DOIs
    Publication statusPublished - 2017

    Keywords

    • Canine epilepsy
    • Epilepsy remission
    • Epileptic seizure recurrence
    • Idiopathic epilepsy
    • Non-epileptic seizures

    Fingerprint

    Dive into the research topics of 'A prospective observational longitudinal study of new-onset seizures and newly diagnosed epilepsy in dogs'. Together they form a unique fingerprint.

    Cite this