A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals

Laura N. Vandenberg, Marlene Agerstrand, Anna Beronius, Claire Beausoleil, Ake Bergman, Lisa A. Bero, C.-G. Bornehag, C. Scott Boyer, Glinda S. Cooper, Ian Cotgreave, David Gee, Philippe Grandjean, Kathryn Z. Guyton, Ulla Hass, Jerrold J. Heindel, Susan Jobling, Karen A. Kidd, Andreas Kortenkamp, Malcolm R. Macleod, Olwenn V. MartinUlf Norinder, Martin Scheringer, Kristina A. Thayer, Jorma Toppari, Paul Whaley, Tracey J. Woodruff, Christina Ruden

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Abstract

Background: The issue of endocrine disrupting chemicals (EDCs) is receiving wide attention from both the scientific and regulatory communities. Recent analyses of the EDC literature have been criticized for failing to use transparent and objective approaches to draw conclusions about the strength of evidence linking EDC exposures to adverse health or environmental outcomes. Systematic review methodologies are ideal for addressing this issue as they provide transparent and consistent approaches to study selection and evaluation. Objective methods are needed for integrating the multiple streams of evidence (epidemiology, wildlife, laboratory animal, in vitro, and in silico data) that are relevant in assessing EDCs.Methods: We have developed a framework for the systematic review and integrated assessment (SYRINA) of EDC studies. The framework was designed for use with the International Program on Chemical Safety (IPCS) and World Health Organization (WHO) definition of an EDC, which requires appraisal of evidence regarding 1) association between exposure and an adverse effect, 2) association between exposure and endocrine disrupting activity, and 3) a plausible link between the adverse effect and the endocrine disrupting activity.Results: Building from existing methodologies for evaluating and synthesizing evidence, the SYRINA framework includes seven steps: 1) Formulate the problem; 2) Develop the review protocol; 3) Identify relevant evidence; 4) Evaluate evidence from individual studies; 5) Summarize and evaluate each stream of evidence; 6) Integrate evidence across all streams; 7) Draw conclusions, make recommendations, and evaluate uncertainties. The proposed method is tailored to the IPCS/WHO definition of an EDC but offers flexibility for use in the context of other definitions of EDCs.Conclusions: When using the SYRINA framework, the overall objective is to provide the evidence base needed to support decision making, including any action to avoid/minimise potential adverse effects of exposures. This framework allows for the evaluation and synthesis of evidence from multiple evidence streams. Finally, a decision regarding regulatory action is not only dependent on the strength of evidence, but also the consequences of action/inaction, e.g. limited or weak evidence may be sufficient to justify action if consequences are serious or irreversible.
Original languageEnglish
Article number74
JournalEnvironmental Health: A Global Access Science Source
Volume15
Issue number1
Number of pages19
ISSN1476-069X
DOIs
Publication statusPublished - 2016

Keywords

  • Adverse effect
  • Endocrine disrupting activity
  • Endocrine disrupting chemicals
  • Epidemiology
  • Evidence integration
  • In vivo
  • Strength of evidence
  • Study evaluation
  • Systematic review
  • Weight of evidence
  • Animalia

Cite this

Vandenberg, Laura N. ; Agerstrand, Marlene ; Beronius, Anna ; Beausoleil, Claire ; Bergman, Ake ; Bero, Lisa A. ; Bornehag, C.-G. ; Boyer, C. Scott ; Cooper, Glinda S. ; Cotgreave, Ian ; Gee, David ; Grandjean, Philippe ; Guyton, Kathryn Z. ; Hass, Ulla ; Heindel, Jerrold J. ; Jobling, Susan ; Kidd, Karen A. ; Kortenkamp, Andreas ; Macleod, Malcolm R. ; Martin, Olwenn V. ; Norinder, Ulf ; Scheringer, Martin ; Thayer, Kristina A. ; Toppari, Jorma ; Whaley, Paul ; Woodruff, Tracey J. ; Ruden, Christina. / A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals. In: Environmental Health: A Global Access Science Source. 2016 ; Vol. 15, No. 1.
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title = "A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals",
abstract = "Background: The issue of endocrine disrupting chemicals (EDCs) is receiving wide attention from both the scientific and regulatory communities. Recent analyses of the EDC literature have been criticized for failing to use transparent and objective approaches to draw conclusions about the strength of evidence linking EDC exposures to adverse health or environmental outcomes. Systematic review methodologies are ideal for addressing this issue as they provide transparent and consistent approaches to study selection and evaluation. Objective methods are needed for integrating the multiple streams of evidence (epidemiology, wildlife, laboratory animal, in vitro, and in silico data) that are relevant in assessing EDCs.Methods: We have developed a framework for the systematic review and integrated assessment (SYRINA) of EDC studies. The framework was designed for use with the International Program on Chemical Safety (IPCS) and World Health Organization (WHO) definition of an EDC, which requires appraisal of evidence regarding 1) association between exposure and an adverse effect, 2) association between exposure and endocrine disrupting activity, and 3) a plausible link between the adverse effect and the endocrine disrupting activity.Results: Building from existing methodologies for evaluating and synthesizing evidence, the SYRINA framework includes seven steps: 1) Formulate the problem; 2) Develop the review protocol; 3) Identify relevant evidence; 4) Evaluate evidence from individual studies; 5) Summarize and evaluate each stream of evidence; 6) Integrate evidence across all streams; 7) Draw conclusions, make recommendations, and evaluate uncertainties. The proposed method is tailored to the IPCS/WHO definition of an EDC but offers flexibility for use in the context of other definitions of EDCs.Conclusions: When using the SYRINA framework, the overall objective is to provide the evidence base needed to support decision making, including any action to avoid/minimise potential adverse effects of exposures. This framework allows for the evaluation and synthesis of evidence from multiple evidence streams. Finally, a decision regarding regulatory action is not only dependent on the strength of evidence, but also the consequences of action/inaction, e.g. limited or weak evidence may be sufficient to justify action if consequences are serious or irreversible.",
keywords = "Adverse effect, Endocrine disrupting activity, Endocrine disrupting chemicals, Epidemiology, Evidence integration, In vivo, Strength of evidence, Study evaluation, Systematic review, Weight of evidence, Animalia",
author = "Vandenberg, {Laura N.} and Marlene Agerstrand and Anna Beronius and Claire Beausoleil and Ake Bergman and Bero, {Lisa A.} and C.-G. Bornehag and Boyer, {C. Scott} and Cooper, {Glinda S.} and Ian Cotgreave and David Gee and Philippe Grandjean and Guyton, {Kathryn Z.} and Ulla Hass and Heindel, {Jerrold J.} and Susan Jobling and Kidd, {Karen A.} and Andreas Kortenkamp and Macleod, {Malcolm R.} and Martin, {Olwenn V.} and Ulf Norinder and Martin Scheringer and Thayer, {Kristina A.} and Jorma Toppari and Paul Whaley and Woodruff, {Tracey J.} and Christina Ruden",
year = "2016",
doi = "10.1186/s12940-016-0156-6",
language = "English",
volume = "15",
journal = "Environmental Health: A Global Access Science Source",
issn = "1476-069X",
publisher = "BioMed Central Ltd.",
number = "1",

}

Vandenberg, LN, Agerstrand, M, Beronius, A, Beausoleil, C, Bergman, A, Bero, LA, Bornehag, C-G, Boyer, CS, Cooper, GS, Cotgreave, I, Gee, D, Grandjean, P, Guyton, KZ, Hass, U, Heindel, JJ, Jobling, S, Kidd, KA, Kortenkamp, A, Macleod, MR, Martin, OV, Norinder, U, Scheringer, M, Thayer, KA, Toppari, J, Whaley, P, Woodruff, TJ & Ruden, C 2016, 'A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals', Environmental Health: A Global Access Science Source, vol. 15, no. 1, 74. https://doi.org/10.1186/s12940-016-0156-6

A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals. / Vandenberg, Laura N.; Agerstrand, Marlene; Beronius, Anna; Beausoleil, Claire; Bergman, Ake; Bero, Lisa A.; Bornehag, C.-G.; Boyer, C. Scott; Cooper, Glinda S.; Cotgreave, Ian; Gee, David; Grandjean, Philippe; Guyton, Kathryn Z.; Hass, Ulla; Heindel, Jerrold J.; Jobling, Susan; Kidd, Karen A.; Kortenkamp, Andreas; Macleod, Malcolm R.; Martin, Olwenn V.; Norinder, Ulf; Scheringer, Martin; Thayer, Kristina A.; Toppari, Jorma; Whaley, Paul; Woodruff, Tracey J.; Ruden, Christina.

In: Environmental Health: A Global Access Science Source, Vol. 15, No. 1, 74, 2016.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals

AU - Vandenberg, Laura N.

AU - Agerstrand, Marlene

AU - Beronius, Anna

AU - Beausoleil, Claire

AU - Bergman, Ake

AU - Bero, Lisa A.

AU - Bornehag, C.-G.

AU - Boyer, C. Scott

AU - Cooper, Glinda S.

AU - Cotgreave, Ian

AU - Gee, David

AU - Grandjean, Philippe

AU - Guyton, Kathryn Z.

AU - Hass, Ulla

AU - Heindel, Jerrold J.

AU - Jobling, Susan

AU - Kidd, Karen A.

AU - Kortenkamp, Andreas

AU - Macleod, Malcolm R.

AU - Martin, Olwenn V.

AU - Norinder, Ulf

AU - Scheringer, Martin

AU - Thayer, Kristina A.

AU - Toppari, Jorma

AU - Whaley, Paul

AU - Woodruff, Tracey J.

AU - Ruden, Christina

PY - 2016

Y1 - 2016

N2 - Background: The issue of endocrine disrupting chemicals (EDCs) is receiving wide attention from both the scientific and regulatory communities. Recent analyses of the EDC literature have been criticized for failing to use transparent and objective approaches to draw conclusions about the strength of evidence linking EDC exposures to adverse health or environmental outcomes. Systematic review methodologies are ideal for addressing this issue as they provide transparent and consistent approaches to study selection and evaluation. Objective methods are needed for integrating the multiple streams of evidence (epidemiology, wildlife, laboratory animal, in vitro, and in silico data) that are relevant in assessing EDCs.Methods: We have developed a framework for the systematic review and integrated assessment (SYRINA) of EDC studies. The framework was designed for use with the International Program on Chemical Safety (IPCS) and World Health Organization (WHO) definition of an EDC, which requires appraisal of evidence regarding 1) association between exposure and an adverse effect, 2) association between exposure and endocrine disrupting activity, and 3) a plausible link between the adverse effect and the endocrine disrupting activity.Results: Building from existing methodologies for evaluating and synthesizing evidence, the SYRINA framework includes seven steps: 1) Formulate the problem; 2) Develop the review protocol; 3) Identify relevant evidence; 4) Evaluate evidence from individual studies; 5) Summarize and evaluate each stream of evidence; 6) Integrate evidence across all streams; 7) Draw conclusions, make recommendations, and evaluate uncertainties. The proposed method is tailored to the IPCS/WHO definition of an EDC but offers flexibility for use in the context of other definitions of EDCs.Conclusions: When using the SYRINA framework, the overall objective is to provide the evidence base needed to support decision making, including any action to avoid/minimise potential adverse effects of exposures. This framework allows for the evaluation and synthesis of evidence from multiple evidence streams. Finally, a decision regarding regulatory action is not only dependent on the strength of evidence, but also the consequences of action/inaction, e.g. limited or weak evidence may be sufficient to justify action if consequences are serious or irreversible.

AB - Background: The issue of endocrine disrupting chemicals (EDCs) is receiving wide attention from both the scientific and regulatory communities. Recent analyses of the EDC literature have been criticized for failing to use transparent and objective approaches to draw conclusions about the strength of evidence linking EDC exposures to adverse health or environmental outcomes. Systematic review methodologies are ideal for addressing this issue as they provide transparent and consistent approaches to study selection and evaluation. Objective methods are needed for integrating the multiple streams of evidence (epidemiology, wildlife, laboratory animal, in vitro, and in silico data) that are relevant in assessing EDCs.Methods: We have developed a framework for the systematic review and integrated assessment (SYRINA) of EDC studies. The framework was designed for use with the International Program on Chemical Safety (IPCS) and World Health Organization (WHO) definition of an EDC, which requires appraisal of evidence regarding 1) association between exposure and an adverse effect, 2) association between exposure and endocrine disrupting activity, and 3) a plausible link between the adverse effect and the endocrine disrupting activity.Results: Building from existing methodologies for evaluating and synthesizing evidence, the SYRINA framework includes seven steps: 1) Formulate the problem; 2) Develop the review protocol; 3) Identify relevant evidence; 4) Evaluate evidence from individual studies; 5) Summarize and evaluate each stream of evidence; 6) Integrate evidence across all streams; 7) Draw conclusions, make recommendations, and evaluate uncertainties. The proposed method is tailored to the IPCS/WHO definition of an EDC but offers flexibility for use in the context of other definitions of EDCs.Conclusions: When using the SYRINA framework, the overall objective is to provide the evidence base needed to support decision making, including any action to avoid/minimise potential adverse effects of exposures. This framework allows for the evaluation and synthesis of evidence from multiple evidence streams. Finally, a decision regarding regulatory action is not only dependent on the strength of evidence, but also the consequences of action/inaction, e.g. limited or weak evidence may be sufficient to justify action if consequences are serious or irreversible.

KW - Adverse effect

KW - Endocrine disrupting activity

KW - Endocrine disrupting chemicals

KW - Epidemiology

KW - Evidence integration

KW - In vivo

KW - Strength of evidence

KW - Study evaluation

KW - Systematic review

KW - Weight of evidence

KW - Animalia

U2 - 10.1186/s12940-016-0156-6

DO - 10.1186/s12940-016-0156-6

M3 - Journal article

C2 - 27412149

VL - 15

JO - Environmental Health: A Global Access Science Source

JF - Environmental Health: A Global Access Science Source

SN - 1476-069X

IS - 1

M1 - 74

ER -