A Pressure Controlled Pinched Flow Fractionation Device for Continuous Particle Separation

Thomas Lehrmann Christiansen, Jacqueline Trosborg, Simone Tanzi, Simon Tylsgaard Larsen, Rafael J. Taboryski

    Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review


    In this work the problem of separating small particles of di↵erent sizes is solved by developing a simple microfluidic device using pinched flow fractionation (PFF), a technique originally presented by Yamada et al. in 2004 [1]. The present work takes the concept of PFF to the next level by making the device tunable using a simple pressure control. Through analytical calculations and FEM simulations in COMSOL, the required dimensions and operating pressures of the device was determined. The device was subsequently fabricated by injection molding of a COC TOPAS grade 5013 polymer (TOPAS Advanced Polymers GmbH) using a micro machined silicon master. The functionality of the device was confirmed using polymer beads, and by adjusting the pressure accordingly a complete separation of 2 μm and 4.5 μm beads was demonstrated.
    Original languageEnglish
    Title of host publicationProceedings of NSTI-Nanotech 2012
    Publication date2012
    ISBN (Electronic)978-1-4665-6275-2
    Publication statusPublished - 2012
    EventNanotech 2012: Conference & Expo - Santa Clara Convention Center, Santa Clara, United States
    Duration: 18 Jun 201221 Jun 2012
    Conference number: 15


    ConferenceNanotech 2012
    LocationSanta Clara Convention Center
    Country/TerritoryUnited States
    CitySanta Clara


    • Pinched flow fractionation
    • Pressure control
    • Modified liga process
    • Injection molding
    • Cleanroom processing
    • Microfluidics
    • Point-of-care


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