A pragmatic approach for human risk assessment of chemical mixtures

Research output: Contribution to journalJournal article – Annual report year: 2019Researchpeer-review

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A pragmatic approach for human risk assessment of chemical mixtures. / Boberg, Julie; Dybdahl, Marianne; Petersen, Annette; Hass, Ulla; Svingen, Terje; Vinggaard, Anne Marie.

In: Current Opinion in Toxicology, Vol. 15, 2019, p. 1-7.

Research output: Contribution to journalJournal article – Annual report year: 2019Researchpeer-review

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@article{45e7a40874804bf18c21be7c7fa00320,
title = "A pragmatic approach for human risk assessment of chemical mixtures",
abstract = "Humans are continuously exposed to complex chemical mixtures from foods and the environment. Due to our inadequate understanding of mixture effects, tools to assess the combined risk of mixed chemical exposures have been difficult to develop. In recent years, regulatory authorities across the world have made considerable progress towards developing pragmatic frameworks to deal with combined exposure to multiple chemicals for risk assessment purposes. These approaches require a high level of information about chemical exposures and toxicities, information that often is lacking. We see this data gap as delaying urgently needed improvements in chemical safety. Herein, we present a pragmatic step-by-step procedure for mixture risk assessment and propose tools for grouping of chemicals. Until we have a better understanding of adverse outcome pathways, we suggest that grouping of chemicals for mixture risk assessment be based on integrated in vivo and in vitro data, read-across as well as computational methods such as QSAR models or integrative systems biology. These latter methods can be used to predict inherent hazards or modes/mechanisms of action and to group the chemicals in cases where no experimental data exist.",
keywords = "Risk assessment, Mixtures, Toxicology, Hazard index",
author = "Julie Boberg and Marianne Dybdahl and Annette Petersen and Ulla Hass and Terje Svingen and Vinggaard, {Anne Marie}",
year = "2019",
doi = "10.1016/j.cotox.2018.11.004",
language = "English",
volume = "15",
pages = "1--7",
journal = "Current Opinion in Toxicology",
issn = "2468-2020",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - A pragmatic approach for human risk assessment of chemical mixtures

AU - Boberg, Julie

AU - Dybdahl, Marianne

AU - Petersen, Annette

AU - Hass, Ulla

AU - Svingen, Terje

AU - Vinggaard, Anne Marie

PY - 2019

Y1 - 2019

N2 - Humans are continuously exposed to complex chemical mixtures from foods and the environment. Due to our inadequate understanding of mixture effects, tools to assess the combined risk of mixed chemical exposures have been difficult to develop. In recent years, regulatory authorities across the world have made considerable progress towards developing pragmatic frameworks to deal with combined exposure to multiple chemicals for risk assessment purposes. These approaches require a high level of information about chemical exposures and toxicities, information that often is lacking. We see this data gap as delaying urgently needed improvements in chemical safety. Herein, we present a pragmatic step-by-step procedure for mixture risk assessment and propose tools for grouping of chemicals. Until we have a better understanding of adverse outcome pathways, we suggest that grouping of chemicals for mixture risk assessment be based on integrated in vivo and in vitro data, read-across as well as computational methods such as QSAR models or integrative systems biology. These latter methods can be used to predict inherent hazards or modes/mechanisms of action and to group the chemicals in cases where no experimental data exist.

AB - Humans are continuously exposed to complex chemical mixtures from foods and the environment. Due to our inadequate understanding of mixture effects, tools to assess the combined risk of mixed chemical exposures have been difficult to develop. In recent years, regulatory authorities across the world have made considerable progress towards developing pragmatic frameworks to deal with combined exposure to multiple chemicals for risk assessment purposes. These approaches require a high level of information about chemical exposures and toxicities, information that often is lacking. We see this data gap as delaying urgently needed improvements in chemical safety. Herein, we present a pragmatic step-by-step procedure for mixture risk assessment and propose tools for grouping of chemicals. Until we have a better understanding of adverse outcome pathways, we suggest that grouping of chemicals for mixture risk assessment be based on integrated in vivo and in vitro data, read-across as well as computational methods such as QSAR models or integrative systems biology. These latter methods can be used to predict inherent hazards or modes/mechanisms of action and to group the chemicals in cases where no experimental data exist.

KW - Risk assessment

KW - Mixtures

KW - Toxicology

KW - Hazard index

U2 - 10.1016/j.cotox.2018.11.004

DO - 10.1016/j.cotox.2018.11.004

M3 - Journal article

VL - 15

SP - 1

EP - 7

JO - Current Opinion in Toxicology

JF - Current Opinion in Toxicology

SN - 2468-2020

ER -