Abstract
| Original language | English |
|---|---|
| Journal | Current Opinion in Toxicology |
| Volume | 15 |
| Pages (from-to) | 1-7 |
| ISSN | 2468-2020 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- Risk assessment
- Mixtures
- Toxicology
- Hazard index
Cite this
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A pragmatic approach for human risk assessment of chemical mixtures. / Boberg, Julie; Dybdahl, Marianne; Petersen, Annette; Hass, Ulla; Svingen, Terje; Vinggaard, Anne Marie.
In: Current Opinion in Toxicology, Vol. 15, 2019, p. 1-7.Research output: Contribution to journal › Journal article › Research › peer-review
TY - JOUR
T1 - A pragmatic approach for human risk assessment of chemical mixtures
AU - Boberg, Julie
AU - Dybdahl, Marianne
AU - Petersen, Annette
AU - Hass, Ulla
AU - Svingen, Terje
AU - Vinggaard, Anne Marie
PY - 2019
Y1 - 2019
N2 - Humans are continuously exposed to complex chemical mixtures from foods and the environment. Due to our inadequate understanding of mixture effects, tools to assess the combined risk of mixed chemical exposures have been difficult to develop. In recent years, regulatory authorities across the world have made considerable progress towards developing pragmatic frameworks to deal with combined exposure to multiple chemicals for risk assessment purposes. These approaches require a high level of information about chemical exposures and toxicities, information that often is lacking. We see this data gap as delaying urgently needed improvements in chemical safety. Herein, we present a pragmatic step-by-step procedure for mixture risk assessment and propose tools for grouping of chemicals. Until we have a better understanding of adverse outcome pathways, we suggest that grouping of chemicals for mixture risk assessment be based on integrated in vivo and in vitro data, read-across as well as computational methods such as QSAR models or integrative systems biology. These latter methods can be used to predict inherent hazards or modes/mechanisms of action and to group the chemicals in cases where no experimental data exist.
AB - Humans are continuously exposed to complex chemical mixtures from foods and the environment. Due to our inadequate understanding of mixture effects, tools to assess the combined risk of mixed chemical exposures have been difficult to develop. In recent years, regulatory authorities across the world have made considerable progress towards developing pragmatic frameworks to deal with combined exposure to multiple chemicals for risk assessment purposes. These approaches require a high level of information about chemical exposures and toxicities, information that often is lacking. We see this data gap as delaying urgently needed improvements in chemical safety. Herein, we present a pragmatic step-by-step procedure for mixture risk assessment and propose tools for grouping of chemicals. Until we have a better understanding of adverse outcome pathways, we suggest that grouping of chemicals for mixture risk assessment be based on integrated in vivo and in vitro data, read-across as well as computational methods such as QSAR models or integrative systems biology. These latter methods can be used to predict inherent hazards or modes/mechanisms of action and to group the chemicals in cases where no experimental data exist.
KW - Risk assessment
KW - Mixtures
KW - Toxicology
KW - Hazard index
U2 - 10.1016/j.cotox.2018.11.004
DO - 10.1016/j.cotox.2018.11.004
M3 - Journal article
VL - 15
SP - 1
EP - 7
JO - Current Opinion in Toxicology
JF - Current Opinion in Toxicology
SN - 2468-2020
ER -