A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: A double-blinded randomized placebo-controlled 1-year intervention

H.T. Viljakainen; A.M. Natri; M. Karkkainen; M.M. Huttunen; A. Palssa; Jette Jakobsen; K.D. Cashman; C. Mølgaard; C. Lamberg-Allardt

A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: A double-blinded randomized placebo-controlled 1-year intervention

H.T. Viljakainen, A.M. Natri, M. Karkkainen, M.M. Huttunen, A. Palssa, Jette Jakobsen, K.D. Cashman, C. Mølgaard, C. Lamberg-Allardt

National Food Institute

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The effect of vitamin D supplementation on bone mineral augmentation in 212 adolescent girls with adequate calcium intake was studied in a randomized placebo-controlled setting. Bone mineral augmentation determined by DXA increased with supplementation both in the femur and the lumbar vertebrae in a dose-responsive manner. Supplementation decreased the urinary excretion of resorption markers, but had no impact on formation markers.

Original language	English
Journal	Journal of Bone and Mineral Research
Volume	21
Issue number	6
Pages (from-to)	836-844
ISSN	0884-0431
Publication status	Published - 2006

Keywords

vitamin D-3 supplementation
adolescent girls
adequate calcium intake
bone mineral augmentation

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Viljakainen, H. T., Natri, A. M., Karkkainen, M., Huttunen, M. M., Palssa, A., Jakobsen, J., Cashman, K. D., Mølgaard, C., & Lamberg-Allardt, C. (2006). A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: A double-blinded randomized placebo-controlled 1-year intervention. Journal of Bone and Mineral Research, 21(6), 836-844.

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abstract = "The effect of vitamin D supplementation on bone mineral augmentation in 212 adolescent girls with adequate calcium intake was studied in a randomized placebo-controlled setting. Bone mineral augmentation determined by DXA increased with supplementation both in the femur and the lumbar vertebrae in a dose-responsive manner. Supplementation decreased the urinary excretion of resorption markers, but had no impact on formation markers.",

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Viljakainen, HT, Natri, AM, Karkkainen, M, Huttunen, MM, Palssa, A, Jakobsen, J, Cashman, KD, Mølgaard, C & Lamberg-Allardt, C 2006, 'A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: A double-blinded randomized placebo-controlled 1-year intervention', Journal of Bone and Mineral Research, vol. 21, no. 6, pp. 836-844.

A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: A double-blinded randomized placebo-controlled 1-year intervention. / Viljakainen, H.T.; Natri, A.M.; Karkkainen, M. et al.
In: Journal of Bone and Mineral Research, Vol. 21, No. 6, 2006, p. 836-844.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: A double-blinded randomized placebo-controlled 1-year intervention

AU - Viljakainen, H.T.

AU - Natri, A.M.

AU - Karkkainen, M.

AU - Huttunen, M.M.

AU - Palssa, A.

AU - Jakobsen, Jette

AU - Cashman, K.D.

AU - Mølgaard, C.

AU - Lamberg-Allardt, C.

PY - 2006

Y1 - 2006

N2 - The effect of vitamin D supplementation on bone mineral augmentation in 212 adolescent girls with adequate calcium intake was studied in a randomized placebo-controlled setting. Bone mineral augmentation determined by DXA increased with supplementation both in the femur and the lumbar vertebrae in a dose-responsive manner. Supplementation decreased the urinary excretion of resorption markers, but had no impact on formation markers.

AB - The effect of vitamin D supplementation on bone mineral augmentation in 212 adolescent girls with adequate calcium intake was studied in a randomized placebo-controlled setting. Bone mineral augmentation determined by DXA increased with supplementation both in the femur and the lumbar vertebrae in a dose-responsive manner. Supplementation decreased the urinary excretion of resorption markers, but had no impact on formation markers.

KW - vitamin D-3 supplementation

KW - adolescent girls

KW - adequate calcium intake

KW - bone mineral augmentation

M3 - Journal article

SN - 0884-0431

VL - 21

SP - 836

EP - 844

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

IS - 6

ER -

A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: A double-blinded randomized placebo-controlled 1-year intervention

Abstract

Keywords

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