A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: A double-blinded randomized placebo-controlled 1-year intervention

H.T. Viljakainen, A.M. Natri, M. Karkkainen, M.M. Huttunen, A. Palssa, Jette Jakobsen, K.D. Cashman, C. Mølgaard, C. Lamberg-Allardt

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The effect of vitamin D supplementation on bone mineral augmentation in 212 adolescent girls with adequate calcium intake was studied in a randomized placebo-controlled setting. Bone mineral augmentation determined by DXA increased with supplementation both in the femur and the lumbar vertebrae in a dose-responsive manner. Supplementation decreased the urinary excretion of resorption markers, but had no impact on formation markers.
Original languageEnglish
JournalJournal of Bone and Mineral Research
Volume21
Issue number6
Pages (from-to)836-844
ISSN0884-0431
Publication statusPublished - 2006

Keywords

  • vitamin D-3 supplementation
  • adolescent girls
  • adequate calcium intake
  • bone mineral augmentation

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