A Point-Wise Quantification of Asymmetry Using Deformation Fields: Application to the Study of the Crouzon Mouse Model

Hildur Ólafsdóttir, Stephanie Lanche, Tron Andre Darvann, Nuno Vibe Hermann, Rasmus Larsen, Bjarne Kjær Ersbøll, Estanislao Oubel, Alejandro F. Frangi, Per Larsen, Chad A. Perlyn, Gillian M. Morriss-Kay, Sven Kreiborg

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

    Abstract

    This paper introduces a novel approach to quantify asymmetry in each point of a surface. The measure is based on analysing displacement vectors resulting from nonrigid image registration. A symmetric atlas, generated from control subjects is registered to a given subject image. A comparison of the resulting displacement vectors on the left and right side of the symmetry plane, gives a point-wise measure of asymmetry. The asymmetry measure was applied to the study of Crouzon syndrome using Micro CT scans of genetically modified mice. Crouzon syndrome is characterised by the premature fusion of cranial sutures, which gives rise to a highly asymmetric growth. Quantification and localisation of this asymmetry is of high value with respect to surgery planning and treatment evaluation. Using the proposed method, asymmetry was calculated in each point of the surface of Crouzon mice and wild-type mice (controls). Asymmetry appeared in similar regions for the two groups but the Crouzon mice were found significantly more asymmetric. The localisation ability of the method was in good agreement with ratings from a clinical expert. Validating the quantification ability is a less trivial task due to the lack of a gold standard. Nevertheless, a comparison with a different, but less accurate measure of asymmetry revealed good correlation.
    Original languageEnglish
    Title of host publicationLecture Notes in computer Science : Medical Image Computing and Computer Assisted interventions - MICCAI 2007
    Place of PublicationBerlin / Heidelberg
    PublisherSpringer
    Publication date2007
    Pages452-459
    ISBN (Print)978-3-540-75758-0
    DOIs
    Publication statusPublished - 2007
    Event10th International Conference on Medical Image Computing and Computer-Assisted Intervention - Brisbane, Australia
    Duration: 29 Oct 20072 Nov 2007
    Conference number: 10

    Conference

    Conference10th International Conference on Medical Image Computing and Computer-Assisted Intervention
    Number10
    CountryAustralia
    CityBrisbane
    Period29/10/200702/11/2007
    SeriesLecture Notes in Computer Science
    Number4792

    Keywords

    • Image registration
    • Micro CT
    • Asymmetry
    • Mouse model
    • Crouzon syndrome

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