A Photolabile Linker for the Solid-Phase Synthesis of Peptide Hydrazides and Heterocycles

Katrine Qvortrup, Vitaly V. Komnatnyy, Thomas Eiland Nielsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A photolabile hydrazine linker for the solid-phase synthesis of peptide hydrazides and hydrazine-derived heterocycles is presented. The developed protocols enable the efficient synthesis of structurally diverse peptide hydrazides derived from the standard amino adds, including those with side-chain protected residues at the C-terminal of the resulting peptide hydrazide, and are useful for the synthesis of dihydropyrano[2,3-c]pyrazoles. The linker is compatible with most commonly used coupling reagents and protecting groups for solid-phase peptide synthesis.
Original languageEnglish
JournalOrganic Letters
Volume16
Issue number18
Pages (from-to)4782-4785
ISSN1523-7060
DOIs
Publication statusPublished - 2014

Keywords

  • CHEMISTRY,
  • CONVERGENT CHEMICAL-SYNTHESIS
  • HYDROXYMETHYL RESIN
  • LIGATION
  • PROTEIN
  • DERIVATIVES
  • ACID
  • AGENTS

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