A photolabile linker for the solid-phase synthesis of 4-substituted NH-1,2,3-triazoles

Katrine Qvortrup; Thomas Eiland Nielsen

doi:10.1039/c0cc05274d

A photolabile linker for the solid-phase synthesis of 4-substituted NH-1,2,3-triazoles

Katrine Qvortrup, Thomas Eiland Nielsen

Department of Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A novel photolabile linker for solid-phase synthesis is presented. The linker displays an azido handle for copper-catalyzed azide–alkyne cycloaddition reactions with a variety of alkynes, remains intact under typical solid-phase reaction conditions, and enables a mild photolytic release of 4-substituted NH-triazoles in high purity and yield.

Original language	English
Journal	Chemical Communications
Volume	47
Issue number	11
Pages (from-to)	3278-3280
ISSN	1359-7345
DOIs	https://doi.org/10.1039/c0cc05274d
Publication status	Published - 2011

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Electronic supplementary information (ESI) available: Experimental procedures and compound characterization data. See DOI:10.1039/c0cc05274d

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10.1039/c0cc05274d

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title = "A photolabile linker for the solid-phase synthesis of 4-substituted NH-1,2,3-triazoles",

abstract = "A novel photolabile linker for solid-phase synthesis is presented. The linker displays an azido handle for copper-catalyzed azide–alkyne cycloaddition reactions with a variety of alkynes, remains intact under typical solid-phase reaction conditions, and enables a mild photolytic release of 4-substituted NH-triazoles in high purity and yield.",

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doi = "10.1039/c0cc05274d",

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AU - Qvortrup, Katrine

AU - Nielsen, Thomas Eiland

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PY - 2011

Y1 - 2011

N2 - A novel photolabile linker for solid-phase synthesis is presented. The linker displays an azido handle for copper-catalyzed azide–alkyne cycloaddition reactions with a variety of alkynes, remains intact under typical solid-phase reaction conditions, and enables a mild photolytic release of 4-substituted NH-triazoles in high purity and yield.

AB - A novel photolabile linker for solid-phase synthesis is presented. The linker displays an azido handle for copper-catalyzed azide–alkyne cycloaddition reactions with a variety of alkynes, remains intact under typical solid-phase reaction conditions, and enables a mild photolytic release of 4-substituted NH-triazoles in high purity and yield.

U2 - 10.1039/c0cc05274d

DO - 10.1039/c0cc05274d

M3 - Journal article

SN - 1359-7345

VL - 47

SP - 3278

EP - 3280

JO - Chemical Communications

JF - Chemical Communications

IS - 11

ER -

A photolabile linker for the solid-phase synthesis of 4-substituted NH-1,2,3-triazoles

Abstract

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