Abstract
| Original language | English |
|---|---|
| Article number | 110517 |
| Journal | Materials Science and Engineering C: Materials for Biological Applications |
| DOIs | |
| Publication status | Accepted/In press - 2020 |
Keywords
- Mesoporous hollow carbon nanospheres
- Poly(epichlorohydrin)
- pH -sensitive
- Coordination bonding
- Doxorubicin
Cite this
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A pH-sensitive carrier based-on modified hollow mesoporous carbon nanospheres with calcium-latched gate for drug delivery. / Asgari, Shadi ; Pourjavadi, Ali ; Hosseini, Seyed Hassan ; Kadkhodazadeh, Shima.
In: Materials Science and Engineering C: Materials for Biological Applications, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
TY - JOUR
T1 - A pH-sensitive carrier based-on modified hollow mesoporous carbon nanospheres with calcium-latched gate for drug delivery
AU - Asgari, Shadi
AU - Pourjavadi, Ali
AU - Hosseini, Seyed Hassan
AU - Kadkhodazadeh, Shima
PY - 2020
Y1 - 2020
N2 - A novel nanocarrier based-on hollow mesoporous carbon nanospheres (HMCNs) with primary amines on its surface, a large cavity, and good hydrophilicity was synthesized by a hydrothermal reaction. The primary amine functionalities on the mesoporous carbon were used as the initiation sites for growing poly (epichlorohydrin) (PCH) chains. The chlorine groups in the side chain of PCH were replaced with imidazole as the pendant groups. Calcium chloride (CaCl2) was applied as a capping agent. The coordination bonding was formed between pendant imidazole groups and calcium ions. Doxorubicin (DOX) was selected as a model of hydrophilic anticancer drug and was loaded onto the nanocarrier and released through the cleavage of the pH-sensitive coordination bonding. The gating mechanism enables the nanocarrier to store and release the calcium ions and the DOX molecules trapped in the pores. MTT assay toward HeLa cells indicated that the nanocarrier had low toxicity because of the surface modification with the oxygen-rich polymer. The cellular uptake of the pH-sensitive nanocarrier for HeLa cancer cell lines was confirmed by CLSM images and flow cytometry. So, the novel pH-sensitive nanocarrier can be applicable to carry and release both DOX drug and calcium ions for cancer treatment.
AB - A novel nanocarrier based-on hollow mesoporous carbon nanospheres (HMCNs) with primary amines on its surface, a large cavity, and good hydrophilicity was synthesized by a hydrothermal reaction. The primary amine functionalities on the mesoporous carbon were used as the initiation sites for growing poly (epichlorohydrin) (PCH) chains. The chlorine groups in the side chain of PCH were replaced with imidazole as the pendant groups. Calcium chloride (CaCl2) was applied as a capping agent. The coordination bonding was formed between pendant imidazole groups and calcium ions. Doxorubicin (DOX) was selected as a model of hydrophilic anticancer drug and was loaded onto the nanocarrier and released through the cleavage of the pH-sensitive coordination bonding. The gating mechanism enables the nanocarrier to store and release the calcium ions and the DOX molecules trapped in the pores. MTT assay toward HeLa cells indicated that the nanocarrier had low toxicity because of the surface modification with the oxygen-rich polymer. The cellular uptake of the pH-sensitive nanocarrier for HeLa cancer cell lines was confirmed by CLSM images and flow cytometry. So, the novel pH-sensitive nanocarrier can be applicable to carry and release both DOX drug and calcium ions for cancer treatment.
KW - Mesoporous hollow carbon nanospheres
KW - Poly(epichlorohydrin)
KW - pH -sensitive
KW - Coordination bonding
KW - Doxorubicin
U2 - 10.1016/j.msec.2019.110517
DO - 10.1016/j.msec.2019.110517
M3 - Journal article
JO - Materials Science and Engineering C: Materials for Biological Applications
JF - Materials Science and Engineering C: Materials for Biological Applications
SN - 1873-0191
M1 - 110517
ER -