A perspective on the developmental toxicity of inhaled nanoparticles

Karin Sørig Hougaard; Luisa Campagnolo; Pascale Chavatte-Palmer; Anne Tarrade; Delphine Rousseau-Ralliard; Sarah Valentino; Margriet V. D. Z. Park; Wim H. de Jong; Gerrit Wolterink; Aldert H. Piersma; Bryony L. Ross; Gary R. Hutchison; Jitka Stilund Hansen; Ulla Birgitte Vogel; Petra Jackson; Rémy Slama; Antonio Pietroiusti; Flemming R. Cassee

doi:10.1016/j.reprotox.2015.05.015

A perspective on the developmental toxicity of inhaled nanoparticles

Karin Sørig Hougaard, Luisa Campagnolo, Pascale Chavatte-Palmer, Anne Tarrade, Delphine Rousseau-Ralliard, Sarah Valentino, Margriet V. D. Z. Park, Wim H. de Jong, Gerrit Wolterink, Aldert H. Piersma, Bryony L. Ross, Gary R. Hutchison, Jitka Stilund Hansen, Ulla Birgitte Vogel, Petra Jackson, Rémy Slama, Antonio Pietroiusti, Flemming R. Cassee

National Food Institute

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Abstract

This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experimental animal studies of NP and air pollution particles. Overall, it is plausible that NP may translocate from the respiratory tract to the placenta and fetus, but also that adverse effects may occur secondarily to maternal inflammatory responses. The limited database describes several organ systems in the offspring to be potentially sensitive to maternal inhalation of particles, but large uncertainties exist about the implications for embryo-fetal development and health later in life. Clearly, the potential for hazard remains to be characterized. Considering the increased production and application of nanomaterials and related consumer products a testing strategy for NP should be established. Due to large gaps in data, significant amounts of groundwork are warranted for a testing strategy to be established on a sound scientific basis.

Original language	English
Journal	Reproductive Toxicology
Volume	56
Issue number	SI
Pages (from-to)	118-140
Number of pages	23
ISSN	0890-6238
DOIs	https://doi.org/10.1016/j.reprotox.2015.05.015
Publication status	Published - 2015

Bibliographical note

Keywords

Developmental toxicity
Inhalation
Instillation
Nanomaterial
Nanoparticles
Pregnancy
Reproductive toxicity
Ultrafine particles

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Hougaard, K. S., Campagnolo, L., Chavatte-Palmer, P., Tarrade, A., Rousseau-Ralliard, D., Valentino, S., Park, M. V. D. Z., de Jong, W. H., Wolterink, G., Piersma, A. H., Ross, B. L., Hutchison, G. R., Hansen, J. S., Vogel, U. B., Jackson, P., Slama, R., Pietroiusti, A., & Cassee, F. R. (2015). A perspective on the developmental toxicity of inhaled nanoparticles. Reproductive Toxicology, 56(SI), 118-140. https://doi.org/10.1016/j.reprotox.2015.05.015

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title = "A perspective on the developmental toxicity of inhaled nanoparticles",

abstract = "This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experimental animal studies of NP and air pollution particles. Overall, it is plausible that NP may translocate from the respiratory tract to the placenta and fetus, but also that adverse effects may occur secondarily to maternal inflammatory responses. The limited database describes several organ systems in the offspring to be potentially sensitive to maternal inhalation of particles, but large uncertainties exist about the implications for embryo-fetal development and health later in life. Clearly, the potential for hazard remains to be characterized. Considering the increased production and application of nanomaterials and related consumer products a testing strategy for NP should be established. Due to large gaps in data, significant amounts of groundwork are warranted for a testing strategy to be established on a sound scientific basis. ",

keywords = "Developmental toxicity, Inhalation, Instillation, Nanomaterial, Nanoparticles, Pregnancy, Reproductive toxicity, Ultrafine particles",

author = "Hougaard, {Karin S{\o}rig} and Luisa Campagnolo and Pascale Chavatte-Palmer and Anne Tarrade and Delphine Rousseau-Ralliard and Sarah Valentino and Park, {Margriet V. D. Z.} and {de Jong}, {Wim H.} and Gerrit Wolterink and Piersma, {Aldert H.} and Ross, {Bryony L.} and Hutchison, {Gary R.} and Hansen, {Jitka Stilund} and Vogel, {Ulla Birgitte} and Petra Jackson and R{\'e}my Slama and Antonio Pietroiusti and Cassee, {Flemming R.}",

note = "{\textcopyright} 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license",

year = "2015",

doi = "10.1016/j.reprotox.2015.05.015",

language = "English",

volume = "56",

pages = "118--140",

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Hougaard, KS, Campagnolo, L, Chavatte-Palmer, P, Tarrade, A, Rousseau-Ralliard, D, Valentino, S, Park, MVDZ, de Jong, WH, Wolterink, G, Piersma, AH, Ross, BL, Hutchison, GR, Hansen, JS, Vogel, UB, Jackson, P, Slama, R, Pietroiusti, A & Cassee, FR 2015, 'A perspective on the developmental toxicity of inhaled nanoparticles', Reproductive Toxicology, vol. 56, no. SI, pp. 118-140. https://doi.org/10.1016/j.reprotox.2015.05.015

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T1 - A perspective on the developmental toxicity of inhaled nanoparticles

AU - Hougaard, Karin Sørig

AU - Campagnolo, Luisa

AU - Chavatte-Palmer, Pascale

AU - Tarrade, Anne

AU - Rousseau-Ralliard, Delphine

AU - Valentino, Sarah

AU - Park, Margriet V. D. Z.

AU - de Jong, Wim H.

AU - Wolterink, Gerrit

AU - Piersma, Aldert H.

AU - Ross, Bryony L.

AU - Hutchison, Gary R.

AU - Hansen, Jitka Stilund

AU - Vogel, Ulla Birgitte

AU - Jackson, Petra

AU - Slama, Rémy

AU - Pietroiusti, Antonio

AU - Cassee, Flemming R.

PY - 2015

Y1 - 2015

N2 - This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experimental animal studies of NP and air pollution particles. Overall, it is plausible that NP may translocate from the respiratory tract to the placenta and fetus, but also that adverse effects may occur secondarily to maternal inflammatory responses. The limited database describes several organ systems in the offspring to be potentially sensitive to maternal inhalation of particles, but large uncertainties exist about the implications for embryo-fetal development and health later in life. Clearly, the potential for hazard remains to be characterized. Considering the increased production and application of nanomaterials and related consumer products a testing strategy for NP should be established. Due to large gaps in data, significant amounts of groundwork are warranted for a testing strategy to be established on a sound scientific basis.

AB - This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experimental animal studies of NP and air pollution particles. Overall, it is plausible that NP may translocate from the respiratory tract to the placenta and fetus, but also that adverse effects may occur secondarily to maternal inflammatory responses. The limited database describes several organ systems in the offspring to be potentially sensitive to maternal inhalation of particles, but large uncertainties exist about the implications for embryo-fetal development and health later in life. Clearly, the potential for hazard remains to be characterized. Considering the increased production and application of nanomaterials and related consumer products a testing strategy for NP should be established. Due to large gaps in data, significant amounts of groundwork are warranted for a testing strategy to be established on a sound scientific basis.

KW - Developmental toxicity

KW - Inhalation

KW - Instillation

KW - Nanomaterial

KW - Nanoparticles

KW - Pregnancy

KW - Reproductive toxicity

KW - Ultrafine particles

U2 - 10.1016/j.reprotox.2015.05.015

DO - 10.1016/j.reprotox.2015.05.015

M3 - Journal article

C2 - 26050605

SN - 0890-6238

VL - 56

SP - 118

EP - 140

JO - Reproductive Toxicology

JF - Reproductive Toxicology

IS - SI

ER -

A perspective on the developmental toxicity of inhaled nanoparticles

Abstract

Bibliographical note

Keywords

Access to Document

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