A perspective on PSE in pharmaceutical process development and innovation

Krist Gernaey; Albert Emili Cervera Padrell; John Woodley

doi:10.1016/j.compchemeng.2012.02.022

A perspective on PSE in pharmaceutical process development and innovation

Krist Gernaey, Albert Emili Cervera Padrell, John Woodley

Department of Chemical and Biochemical Engineering

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The pharmaceutical industry is under growing pressure to increase efficiency, both in production and in process development. This paper discusses the central role of Process Systems Engineering (PSE) methods and tools in pharmaceutical process development and innovation, and searches for answers to questions such as: Which PSE methods can be applied readily? Where is more method development needed? The paper covers key subjects for development of economically and environmentally sustainable pharmaceutical processes, including Process Analytical Technology in its broadest sense, continuous pharmaceutical manufacturing and green processes, and is illustrated with a series of short examples taken from the literature and ongoing research projects.

Original language	English
Journal	Computers & Chemical Engineering
Volume	42
Issue number	Special issue of ESCAPE-21
Pages (from-to)	15-29
ISSN	0098-1354
DOIs	https://doi.org/10.1016/j.compchemeng.2012.02.022
Publication status	Published - 2012

Bibliographical note

Based on paper presented at the 21st European Symposium on Computer-Aided Process Engineering (ESCAPE-21), Greece 2011.

Keywords

Continuous pharmaceutical manufacturing
Design space
PAT
Pharmaceutical production
Process development
Sustainability

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title = "A perspective on PSE in pharmaceutical process development and innovation",

abstract = "The pharmaceutical industry is under growing pressure to increase efficiency, both in production and in process development. This paper discusses the central role of Process Systems Engineering (PSE) methods and tools in pharmaceutical process development and innovation, and searches for answers to questions such as: Which PSE methods can be applied readily? Where is more method development needed? The paper covers key subjects for development of economically and environmentally sustainable pharmaceutical processes, including Process Analytical Technology in its broadest sense, continuous pharmaceutical manufacturing and green processes, and is illustrated with a series of short examples taken from the literature and ongoing research projects.",

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author = "Krist Gernaey and {Cervera Padrell}, {Albert Emili} and John Woodley",

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AU - Woodley, John

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AB - The pharmaceutical industry is under growing pressure to increase efficiency, both in production and in process development. This paper discusses the central role of Process Systems Engineering (PSE) methods and tools in pharmaceutical process development and innovation, and searches for answers to questions such as: Which PSE methods can be applied readily? Where is more method development needed? The paper covers key subjects for development of economically and environmentally sustainable pharmaceutical processes, including Process Analytical Technology in its broadest sense, continuous pharmaceutical manufacturing and green processes, and is illustrated with a series of short examples taken from the literature and ongoing research projects.

KW - Continuous pharmaceutical manufacturing

KW - Design space

KW - PAT

KW - Pharmaceutical production

KW - Process development

KW - Sustainability

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DO - 10.1016/j.compchemeng.2012.02.022

M3 - Journal article

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JO - Computers & Chemical Engineering

JF - Computers & Chemical Engineering

IS - Special issue of ESCAPE-21

ER -

A perspective on PSE in pharmaceutical process development and innovation

Abstract

Bibliographical note

Keywords

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