A perioperative layered autologous tissue expansion graft for hollow organ repair

Oliver Willacy, Nikolai Juul, Loai Taouzlak, Clara I. Chamorro, Fatemeh Ajallouiean, Magdalena Fossum*

*Corresponding author for this work

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Abstract

Tissue engineering has not been widely adopted in clinical settings for several reasons, including technical challenges, high costs, and regulatory complexity. Here, we introduce the Perioperative Layered Autologous Tissue Expansion graft (PLATE graft), a composite biomaterial and collagen-reinforced construct with autologous epithelium on one side and smooth muscle tissue on the other. Designed to mimic the structure and function of natural hollow organs, the PLATE graft is unique in that it can be produced in a standard operating theatre and is cost-effective. In this proof-of-principle study, we test its regenerative performance in eight different organs, present biomechanical and permeability tests, and finally explore its in vivo performance in live rabbits.

Original languageEnglish
Article numbere25275
JournalHeliyon
Volume10
Issue number3
Number of pages14
ISSN2405-8440
DOIs
Publication statusPublished - 2024

Keywords

  • Biomaterials
  • Hydrogel
  • PLATE graft
  • Tissue engineering
  • Tissue expansion
  • Translational medicine

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