A novel urinary biomarker of type VI collagen formation and endotrophin is associated with loss of kidney function in patients with diabetic nephropathy

Federica Genovese, Daniel Rasmussen, Signe Holm Nielsen, Joseph Haas, James Voelker, Morten Asser Karsdal, Kevin Duffin

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Abstract

INTRODUCTION AND AIMS: Diabetic nephropathy (DN) is the leading cause of CKD in the Western world. Around 50 percent of patients who have had diabetes for more than 20 years develop CKD. Glomerulosclerosis and tubulointerstitial fibrosis are histological features as DN progresses towards end-stage renal disease. Fibrosis is characterized by a dysregulated remodeling of the extracellular matrix (ECM). Collagen type VI (COL VI) is a crucial ECM molecule for the control of tissue organization. It is present at the interface of the glomerular basement membrane and interstitial matrix and its levels have been reported elevated in glomeruli of patients with glomerular diseases and in the mesangium of diabetic patients. During deposition of COL VI, a fragment is released, namely endotrophin (ETP). Endotrophin (ETP), has shown pro- fibrotic potential. We investigated the prognostic potential of COL VI formation and ETP for CKD prog
Original languageEnglish
JournalNephrology, Dialysis, Transplantation
Volume32
Issue numberSuppl. 3
Number of pages1
ISSN0931-0509
DOIs
Publication statusPublished - 2017
Event54th ERA-EDTA Congress - Madrid, Spain
Duration: 3 Jun 20176 Jun 2017
Conference number: 54
http://www.era-edta2017.org/en-US/home

Conference

Conference54th ERA-EDTA Congress
Number54
CountrySpain
CityMadrid
Period03/06/201706/06/2017
Internet address

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