A novel preparation of methyl-β-cyclodextrin from dimethyl carbonate and β-cyclodextrin

Yongjiang Gan; Yimin Zhang; Chuanhao Xiao; Chunyan Zhou; Yucang Zhao

doi:10.1016/j.carres.2010.05.028

A novel preparation of methyl-β-cyclodextrin from dimethyl carbonate and β-cyclodextrin

Yongjiang Gan
, Yimin Zhang
, Chuanhao Xiao
, Chunyan Zhou
, Yucang Zhao

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A novel green synthesis process about methyl-β-cyclodextrin has been investigated through the reaction between β-cyclodextrin and dimethyl carbonate by anhydrous potassium carbonate as catalyst in DMF. The influence of experimental factors including the molar ratio of dimethyl carbonate to β-cyclodextrin, reaction temperature, and reaction time on the average degree of substitution of methyl-β-cyclodextrin was studied. The results show that the average degree of substitution of methyl-β-cyclodextrin can be dependent on the reaction temperature and the molar ratio of raw material primarily. The structures of methyl-β-cyclodextrin were characterized by TLC, IR, MS, 1H NMR, and 13C NMR.

Original language	English
Journal	Carbohydrate Research
Volume	346
Issue number	3
Pages (from-to)	389-392
ISSN	0008-6215
DOIs	https://doi.org/10.1016/j.carres.2010.05.028
Publication status	Published - 2011

Keywords

Dimethyl carbonate
b-Cyclodextrin
NMR
Methyl-b-cyclodextrin
MS

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title = "A novel preparation of methyl-β-cyclodextrin from dimethyl carbonate and β-cyclodextrin",

abstract = "A novel green synthesis process about methyl-β-cyclodextrin has been investigated through the reaction between β-cyclodextrin and dimethyl carbonate by anhydrous potassium carbonate as catalyst in DMF. The influence of experimental factors including the molar ratio of dimethyl carbonate to β-cyclodextrin, reaction temperature, and reaction time on the average degree of substitution of methyl-β-cyclodextrin was studied. The results show that the average degree of substitution of methyl-β-cyclodextrin can be dependent on the reaction temperature and the molar ratio of raw material primarily. The structures of methyl-β-cyclodextrin were characterized by TLC, IR, MS, 1H NMR, and 13C NMR.",

keywords = "Dimethyl carbonate, b-Cyclodextrin, NMR, Methyl-b-cyclodextrin, MS",

author = "Yongjiang Gan and Yimin Zhang and Chuanhao Xiao and Chunyan Zhou and Yucang Zhao",

year = "2011",

doi = "10.1016/j.carres.2010.05.028",

language = "English",

volume = "346",

pages = "389--392",

journal = "Carbohydrate Research",

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T1 - A novel preparation of methyl-β-cyclodextrin from dimethyl carbonate and β-cyclodextrin

AU - Gan, Yongjiang

AU - Zhang, Yimin

AU - Xiao, Chuanhao

AU - Zhou, Chunyan

AU - Zhao, Yucang

PY - 2011

Y1 - 2011

N2 - A novel green synthesis process about methyl-β-cyclodextrin has been investigated through the reaction between β-cyclodextrin and dimethyl carbonate by anhydrous potassium carbonate as catalyst in DMF. The influence of experimental factors including the molar ratio of dimethyl carbonate to β-cyclodextrin, reaction temperature, and reaction time on the average degree of substitution of methyl-β-cyclodextrin was studied. The results show that the average degree of substitution of methyl-β-cyclodextrin can be dependent on the reaction temperature and the molar ratio of raw material primarily. The structures of methyl-β-cyclodextrin were characterized by TLC, IR, MS, 1H NMR, and 13C NMR.

AB - A novel green synthesis process about methyl-β-cyclodextrin has been investigated through the reaction between β-cyclodextrin and dimethyl carbonate by anhydrous potassium carbonate as catalyst in DMF. The influence of experimental factors including the molar ratio of dimethyl carbonate to β-cyclodextrin, reaction temperature, and reaction time on the average degree of substitution of methyl-β-cyclodextrin was studied. The results show that the average degree of substitution of methyl-β-cyclodextrin can be dependent on the reaction temperature and the molar ratio of raw material primarily. The structures of methyl-β-cyclodextrin were characterized by TLC, IR, MS, 1H NMR, and 13C NMR.

KW - Dimethyl carbonate

KW - b-Cyclodextrin

KW - NMR

KW - Methyl-b-cyclodextrin

KW - MS

U2 - 10.1016/j.carres.2010.05.028

DO - 10.1016/j.carres.2010.05.028

M3 - Journal article

SN - 0008-6215

VL - 346

SP - 389

EP - 392

JO - Carbohydrate Research

JF - Carbohydrate Research

IS - 3

ER -

A novel preparation of methyl-β-cyclodextrin from dimethyl carbonate and β-cyclodextrin

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