A novel preparation of methyl-β-cyclodextrin from dimethyl carbonate and β-cyclodextrin

Yongjiang Gan, Yimin Zhang, Chuanhao Xiao, Chunyan Zhou, Yucang Zhao

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A novel green synthesis process about methyl-β-cyclodextrin has been investigated through the reaction between β-cyclodextrin and dimethyl carbonate by anhydrous potassium carbonate as catalyst in DMF. The influence of experimental factors including the molar ratio of dimethyl carbonate to β-cyclodextrin, reaction temperature, and reaction time on the average degree of substitution of methyl-β-cyclodextrin was studied. The results show that the average degree of substitution of methyl-β-cyclodextrin can be dependent on the reaction temperature and the molar ratio of raw material primarily. The structures of methyl-β-cyclodextrin were characterized by TLC, IR, MS, 1H NMR, and 13C NMR.
Original languageEnglish
JournalCarbohydrate Research
Volume346
Issue number3
Pages (from-to)389-392
ISSN0008-6215
DOIs
Publication statusPublished - 2011

Keywords

  • Dimethyl carbonate
  • b-Cyclodextrin
  • NMR
  • Methyl-b-cyclodextrin
  • MS

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