Abstract
Original language | English |
---|---|
Journal | EBioMedicine |
Volume | 2 |
Issue number | 12 |
Pages (from-to) | 1957-1964 |
Number of pages | 8 |
ISSN | 2352-3964 |
DOIs | |
Publication status | Published - 2015 |
Bibliographical note
© 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Keywords
- African American
- ERG
- Genome
- LSAMP
- PTEN
- Prostate cancer
Cite this
}
A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men. / Petrovics, Gyorgy; Li, Hua; Stümpel, Tanja; Tan, Shyh-Han; Young, Denise; Katta, Shilpa; Li, Qiyuan; Ying, Kai; Klocke, Bernward; Ravindranath, Lakshmi; Kohaar, Indu; Chen, Yongmei; Ribli, Dezső; Grote, Korbinian; Zou, Hua; Cheng, Joseph; Dalgard, Clifton L.; Zhang, Shimin; Csabai, Istvan; Kagan, Jacob; Takeda, David; Loda, Massimo; Scherf, Matthias; Seifert, Martin; Gaiser, Timo; McLeod, David G.; Szallasi, Zoltan Imre; Ebner, Reinhard; Werner, Thomas; Sesterhenn, Isabell A; Freedman, Matthew; Dobi, Albert; Srivastava, Shiv.
In: EBioMedicine, Vol. 2, No. 12, 2015, p. 1957-1964.Research output: Contribution to journal › Journal article › Research › peer-review
TY - JOUR
T1 - A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men
AU - Petrovics, Gyorgy
AU - Li, Hua
AU - Stümpel, Tanja
AU - Tan, Shyh-Han
AU - Young, Denise
AU - Katta, Shilpa
AU - Li, Qiyuan
AU - Ying, Kai
AU - Klocke, Bernward
AU - Ravindranath, Lakshmi
AU - Kohaar, Indu
AU - Chen, Yongmei
AU - Ribli, Dezső
AU - Grote, Korbinian
AU - Zou, Hua
AU - Cheng, Joseph
AU - Dalgard, Clifton L.
AU - Zhang, Shimin
AU - Csabai, Istvan
AU - Kagan, Jacob
AU - Takeda, David
AU - Loda, Massimo
AU - Scherf, Matthias
AU - Seifert, Martin
AU - Gaiser, Timo
AU - McLeod, David G.
AU - Szallasi, Zoltan Imre
AU - Ebner, Reinhard
AU - Werner, Thomas
AU - Sesterhenn, Isabell A
AU - Freedman, Matthew
AU - Dobi, Albert
AU - Srivastava, Shiv
N1 - © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
PY - 2015
Y1 - 2015
N2 - Evaluation of cancer genomes in global context is of great interest in light of changing ethnic distribution of the world population. We focused our study on men of African ancestry because of their disproportionately higher rate of prostate cancer (CaP) incidence and mortality. We present a systematic whole genome analyses, revealing alterations that differentiate African American (AA) and Caucasian American (CA) CaP genomes. We discovered a recurrent deletion on chromosome 3q13.31 centering on the LSAMP locus that was prevalent in tumors from AA men (cumulative analyses of 435 patients: whole genome sequence, 14; FISH evaluations, 101; and SNP array, 320 patients). Notably, carriers of this deletion experienced more rapid disease progression. In contrast, PTEN and ERG common driver alterations in CaP were significantly lower in AA prostate tumors compared to prostate tumors from CA. Moreover, the frequency of inter-chromosomal rearrangements was significantly higher in AA than CA tumors. These findings reveal differentially distributed somatic mutations in CaP across ancestral groups, which have implications for precision medicine strategies.
AB - Evaluation of cancer genomes in global context is of great interest in light of changing ethnic distribution of the world population. We focused our study on men of African ancestry because of their disproportionately higher rate of prostate cancer (CaP) incidence and mortality. We present a systematic whole genome analyses, revealing alterations that differentiate African American (AA) and Caucasian American (CA) CaP genomes. We discovered a recurrent deletion on chromosome 3q13.31 centering on the LSAMP locus that was prevalent in tumors from AA men (cumulative analyses of 435 patients: whole genome sequence, 14; FISH evaluations, 101; and SNP array, 320 patients). Notably, carriers of this deletion experienced more rapid disease progression. In contrast, PTEN and ERG common driver alterations in CaP were significantly lower in AA prostate tumors compared to prostate tumors from CA. Moreover, the frequency of inter-chromosomal rearrangements was significantly higher in AA than CA tumors. These findings reveal differentially distributed somatic mutations in CaP across ancestral groups, which have implications for precision medicine strategies.
KW - African American
KW - ERG
KW - Genome
KW - LSAMP
KW - PTEN
KW - Prostate cancer
U2 - 10.1016/j.ebiom.2015.10.028
DO - 10.1016/j.ebiom.2015.10.028
M3 - Journal article
VL - 2
SP - 1957
EP - 1964
JO - EBioMedicine
JF - EBioMedicine
SN - 2352-3964
IS - 12
ER -