A Novel Familial Cardiac Arrhythmia Syndrome with Widespread ST-Segment Depression

Henning Bundgaard; Christian Jøns; Elisabeth Lodder; Jose Maria Gonzalez-Izarzugaza; Jose A. Romero Herrera; Steen Pehrson; Jacob Tfelt-Hansen; Gustav Ahlberg; Morten S Olesen; Anders G Holst; Hein Wellens; Carin  de Villiers; Robert Hastings; Stuart Graham; Arthur A. M.  Wilde; Hugh Watkins; Alex Christensen; Søren Brunak

doi:10.1056/NEJMc1807668

A Novel Familial Cardiac Arrhythmia Syndrome with Widespread ST-Segment Depression

Henning Bundgaard, Christian Jøns, Elisabeth Lodder, Jose Maria Gonzalez-Izarzugaza, Jose A. Romero Herrera, Steen Pehrson, Jacob Tfelt-Hansen, Gustav Ahlberg, Morten S Olesen, Anders G Holst, Hein Wellens, Carin de Villiers, Robert Hastings, Stuart Graham, Arthur A. M. Wilde, Hugh Watkins, Alex Christensen, Søren Brunak

Research output: Contribution to journal › Comment/debate › Research › peer-review

Abstract

To the Editor: Several classic cardiac genetic disorders have been identified from specific electrocardiographic (ECG) patterns.1-3 Here, we describe five unrelated families, from three different countries, with features that appear to represent
a previously unrecognized autosomal dominant syndrome. These families were identified at three tertiary referral centers for patients with known or suspected inherited cardiac disorders (as described in the Supplementary Appendix, available
with the full text of this letter at NEJM.org)

Original language	English
Journal	The New England Journal of Medicine
Volume	379
Pages (from-to)	1780-1782
ISSN	0028-4793
DOIs	https://doi.org/10.1056/NEJMc1807668
Publication status	Published - 2018

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Bundgaard, H., Jøns, C., Lodder, E., Gonzalez-Izarzugaza, J. M., Herrera, J. A. R., Pehrson, S., Tfelt-Hansen, J., Ahlberg, G., Olesen, M. S., Holst, A. G., Wellens, H., de Villiers, C., Hastings, R., Graham, S., Wilde, A. A. M., Watkins, H., Christensen, A., & Brunak, S. (2018). A Novel Familial Cardiac Arrhythmia Syndrome with Widespread ST-Segment Depression. The New England Journal of Medicine, 379, 1780-1782. https://doi.org/10.1056/NEJMc1807668

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title = "A Novel Familial Cardiac Arrhythmia Syndrome with Widespread ST-Segment Depression",

abstract = "To the Editor: Several classic cardiac genetic disorders have been identified from specific electrocardiographic (ECG) patterns.1-3 Here, we describe five unrelated families, from three different countries, with features that appear to representa previously unrecognized autosomal dominant syndrome. These families were identified at three tertiary referral centers for patients with known or suspected inherited cardiac disorders (as described in the Supplementary Appendix, availablewith the full text of this letter at NEJM.org)",

author = "Henning Bundgaard and Christian J{\o}ns and Elisabeth Lodder and Gonzalez-Izarzugaza, {Jose Maria} and Herrera, {Jose A. Romero} and Steen Pehrson and Jacob Tfelt-Hansen and Gustav Ahlberg and Olesen, {Morten S} and Holst, {Anders G} and Hein Wellens and {de Villiers}, Carin and Robert Hastings and Stuart Graham and Wilde, {Arthur A. M.} and Hugh Watkins and Alex Christensen and S{\o}ren Brunak",

year = "2018",

doi = "10.1056/NEJMc1807668",

language = "English",

volume = "379",

pages = "1780--1782",

journal = "The New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachusetts Medical Society",

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Bundgaard, H, Jøns, C, Lodder, E, Gonzalez-Izarzugaza, JM, Herrera, JAR, Pehrson, S, Tfelt-Hansen, J, Ahlberg, G, Olesen, MS, Holst, AG, Wellens, H, de Villiers, C, Hastings, R, Graham, S, Wilde, AAM, Watkins, H, Christensen, A & Brunak, S 2018, 'A Novel Familial Cardiac Arrhythmia Syndrome with Widespread ST-Segment Depression', The New England Journal of Medicine, vol. 379, pp. 1780-1782. https://doi.org/10.1056/NEJMc1807668

TY - JOUR

T1 - A Novel Familial Cardiac Arrhythmia Syndrome with Widespread ST-Segment Depression

AU - Bundgaard, Henning

AU - Jøns, Christian

AU - Lodder, Elisabeth

AU - Gonzalez-Izarzugaza, Jose Maria

AU - Herrera, Jose A. Romero

AU - Pehrson, Steen

AU - Tfelt-Hansen, Jacob

AU - Ahlberg, Gustav

AU - Olesen, Morten S

AU - Holst, Anders G

AU - Wellens, Hein

AU - de Villiers, Carin

AU - Hastings, Robert

AU - Graham, Stuart

AU - Wilde, Arthur A. M.

AU - Watkins, Hugh

AU - Christensen, Alex

AU - Brunak, Søren

PY - 2018

Y1 - 2018

N2 - To the Editor: Several classic cardiac genetic disorders have been identified from specific electrocardiographic (ECG) patterns.1-3 Here, we describe five unrelated families, from three different countries, with features that appear to representa previously unrecognized autosomal dominant syndrome. These families were identified at three tertiary referral centers for patients with known or suspected inherited cardiac disorders (as described in the Supplementary Appendix, availablewith the full text of this letter at NEJM.org)

AB - To the Editor: Several classic cardiac genetic disorders have been identified from specific electrocardiographic (ECG) patterns.1-3 Here, we describe five unrelated families, from three different countries, with features that appear to representa previously unrecognized autosomal dominant syndrome. These families were identified at three tertiary referral centers for patients with known or suspected inherited cardiac disorders (as described in the Supplementary Appendix, availablewith the full text of this letter at NEJM.org)

U2 - 10.1056/NEJMc1807668

DO - 10.1056/NEJMc1807668

M3 - Comment/debate

C2 - 30380381

SN - 0028-4793

VL - 379

SP - 1780

EP - 1782

JO - The New England Journal of Medicine

JF - The New England Journal of Medicine

ER -

A Novel Familial Cardiac Arrhythmia Syndrome with Widespread ST-Segment Depression

Abstract

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