A novel biomarker of laminin turnover is associated with mortality and disease progression in chronic kidney disease

Signe Holm Nielsen; Daniel Guldager Kring Rasmussen; Anthony Fenton; Mark Jesky; Charles Ferro; Morten Karsdal; Federica Genovese; Paul Cockwell

doi:10.1093/ndt/gfx102.SO015

A novel biomarker of laminin turnover is associated with mortality and disease progression in chronic kidney disease

Signe Holm Nielsen, Daniel Guldager Kring Rasmussen, Anthony Fenton, Mark Jesky, Charles Ferro, Morten Karsdal, Federica Genovese, Paul Cockwell

Department of Biotechnology and Biomedicine

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

380 Downloads (Orbit)

Abstract

INTRODUCTION AND AIMS: Patients with chronic kidney disease (CKD) have increased risk of progressing to end-stage renal disease (ESRD) and a high mortality rate. One of the major underlying causes of progression of renal failure is renal fibrosis, which is caused by dysregulated extracellular matrix (ECM) remodeling. The laminin γ1 (LAMC1) chain is a constituent of the laminin types present in the glomerular basement membrane (GBM), and its turnover may be altered in CKD. Fragments of LAMC1 could quantify GBM turnover in human CKD and reflect pathological tissue changes. We developed an immunoassay targeting LG1M, a neo-epitope of LAMC1 generated by matrix metalloproteinases (MMPs). We then measured LG1M levels in serum and urine from a large prospective cohort of patients with high-risk CKD.

Original language	English
Journal	Nephrology, Dialysis, Transplantation
Volume	32
Issue number	Suppl. 3
Number of pages	1
ISSN	0931-0509
DOIs	https://doi.org/10.1093/ndt/gfx102.SO015
Publication status	Published - 2017
Event	54^th ERA-EDTA Congress - Madrid, Spain Duration: 3 Jun 2017 → 6 Jun 2017 Conference number: 54 http://www.era-edta2017.org/en-US/home

Conference

Conference	54^th ERA-EDTA Congress
Number	54
Country/Territory	Spain
City	Madrid
Period	03/06/2017 → 06/06/2017
Internet address	http://www.era-edta2017.org/en-US/home

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/ndt/gfx102.SO015

.pdfFinal published version, 42.6 KB

OpenUrl availability

Full text

Cite this

@article{b808047223a24d70a2b0d7ffd963d26b,

title = "A novel biomarker of laminin turnover is associated with mortality and disease progression in chronic kidney disease",

abstract = "INTRODUCTION AND AIMS: Patients with chronic kidney disease (CKD) have increased risk of progressing to end-stage renal disease (ESRD) and a high mortality rate. One of the major underlying causes of progression of renal failure is renal fibrosis, which is caused by dysregulated extracellular matrix (ECM) remodeling. The laminin γ1 (LAMC1) chain is a constituent of the laminin types present in the glomerular basement membrane (GBM), and its turnover may be altered in CKD. Fragments of LAMC1 could quantify GBM turnover in human CKD and reflect pathological tissue changes. We developed an immunoassay targeting LG1M, a neo-epitope of LAMC1 generated by matrix metalloproteinases (MMPs). We then measured LG1M levels in serum and urine from a large prospective cohort of patients with high-risk CKD.",

author = "Nielsen, {Signe Holm} and {Guldager Kring Rasmussen}, Daniel and Anthony Fenton and Mark Jesky and Charles Ferro and Morten Karsdal and Federica Genovese and Paul Cockwell",

year = "2017",

doi = "10.1093/ndt/gfx102.SO015",

language = "English",

volume = "32",

journal = "Nephrology, Dialysis, Transplantation",

issn = "0931-0509",

publisher = "Oxford University Press",

number = "Suppl. 3",

note = "54<sup>th</sup> ERA-EDTA Congress, ERA-EDTA 2017 ; Conference date: 03-06-2017 Through 06-06-2017",

url = "http://www.era-edta2017.org/en-US/home",

}

A novel biomarker of laminin turnover is associated with mortality and disease progression in chronic kidney disease. / Nielsen, Signe Holm; Guldager Kring Rasmussen, Daniel; Fenton, Anthony et al.
In: Nephrology, Dialysis, Transplantation, Vol. 32, No. Suppl. 3, 2017.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

TY - ABST

T1 - A novel biomarker of laminin turnover is associated with mortality and disease progression in chronic kidney disease

AU - Nielsen, Signe Holm

AU - Guldager Kring Rasmussen, Daniel

AU - Fenton, Anthony

AU - Jesky, Mark

AU - Ferro, Charles

AU - Karsdal, Morten

AU - Genovese, Federica

AU - Cockwell, Paul

N1 - Conference code: 54

PY - 2017

Y1 - 2017

N2 - INTRODUCTION AND AIMS: Patients with chronic kidney disease (CKD) have increased risk of progressing to end-stage renal disease (ESRD) and a high mortality rate. One of the major underlying causes of progression of renal failure is renal fibrosis, which is caused by dysregulated extracellular matrix (ECM) remodeling. The laminin γ1 (LAMC1) chain is a constituent of the laminin types present in the glomerular basement membrane (GBM), and its turnover may be altered in CKD. Fragments of LAMC1 could quantify GBM turnover in human CKD and reflect pathological tissue changes. We developed an immunoassay targeting LG1M, a neo-epitope of LAMC1 generated by matrix metalloproteinases (MMPs). We then measured LG1M levels in serum and urine from a large prospective cohort of patients with high-risk CKD.

AB - INTRODUCTION AND AIMS: Patients with chronic kidney disease (CKD) have increased risk of progressing to end-stage renal disease (ESRD) and a high mortality rate. One of the major underlying causes of progression of renal failure is renal fibrosis, which is caused by dysregulated extracellular matrix (ECM) remodeling. The laminin γ1 (LAMC1) chain is a constituent of the laminin types present in the glomerular basement membrane (GBM), and its turnover may be altered in CKD. Fragments of LAMC1 could quantify GBM turnover in human CKD and reflect pathological tissue changes. We developed an immunoassay targeting LG1M, a neo-epitope of LAMC1 generated by matrix metalloproteinases (MMPs). We then measured LG1M levels in serum and urine from a large prospective cohort of patients with high-risk CKD.

U2 - 10.1093/ndt/gfx102.SO015

DO - 10.1093/ndt/gfx102.SO015

M3 - Conference abstract in journal

SN - 0931-0509

VL - 32

JO - Nephrology, Dialysis, Transplantation

JF - Nephrology, Dialysis, Transplantation

IS - Suppl. 3

T2 - 54<sup>th</sup> ERA-EDTA Congress

Y2 - 3 June 2017 through 6 June 2017

ER -

A novel biomarker of laminin turnover is associated with mortality and disease progression in chronic kidney disease

Abstract

Conference

UN SDGs

Access to Document

OpenUrl availability

Fingerprint

Cite this