A novel biomarker of laminin turnover is associated with mortality and disease progression in chronic kidney disease

Signe Holm Nielsen, Daniel Guldager Kring Rasmussen, Anthony Fenton, Mark Jesky, Charles Ferro, Morten Karsdal, Federica Genovese, Paul Cockwell

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Abstract

INTRODUCTION AND AIMS: Patients with chronic kidney disease (CKD) have increased risk of progressing to end-stage renal disease (ESRD) and a high mortality rate. One of the major underlying causes of progression of renal failure is renal fibrosis, which is caused by dysregulated extracellular matrix (ECM) remodeling. The laminin γ1 (LAMC1) chain is a constituent of the laminin types present in the glomerular basement membrane (GBM), and its turnover may be altered in CKD. Fragments of LAMC1 could quantify GBM turnover in human CKD and reflect pathological tissue changes. We developed an immunoassay targeting LG1M, a neo-epitope of LAMC1 generated by matrix metalloproteinases (MMPs). We then measured LG1M levels in serum and urine from a large prospective cohort of patients with high-risk CKD.
Original languageEnglish
JournalNephrology, Dialysis, Transplantation
Volume32
Issue numberSuppl. 3
Number of pages1
ISSN0931-0509
DOIs
Publication statusPublished - 2017
Event54th ERA-EDTA Congress - Madrid, Spain
Duration: 3 Jun 20176 Jun 2017
Conference number: 54
http://www.era-edta2017.org/en-US/home

Conference

Conference54th ERA-EDTA Congress
Number54
CountrySpain
CityMadrid
Period03/06/201706/06/2017
Internet address

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