A new strategy for synthesizing AgInS2 quantum dots emitting brightly in near-infrared window for in vivo imaging

Lianjiang Tan, Shuiping Liu, Xiaoqiang Li, Ioannis S. Chronakis, Yumei Shen

Research output: Contribution to journalJournal articleResearchpeer-review


A new strategy for fabricating water-dispersible AgInS2 quantum dots (QDs) with bright near-infrared (NIR) emission is demonstrated. A type of multidentate polymer (MDP) was synthesized and utilized as a compact capping ligand for the AgInS2 QDs. Using silver nitrate, indium acetate and sulfur-hydrazine hydrate complex as the precursors, MDP-capping AgInS2 QDs were synthesized in aqueous solution at room temperature. Characterization indicates that the MDP-capping AgInS2 QDs are highly photoluminescent in NIR window and possess good photostability. Also, the QDs are stable in different media and have low cytotoxicity. Nude mice photoluminescence imaging shows that the MDP-capping AgInS2 QDs can be well applied to in vivo imaging. These readily prepared NIR fluorescent nanocrystals have huge potential for biomedical applications.
Original languageEnglish
JournalColloids and Surfaces B: Biointerfaces
Pages (from-to)222-229
Number of pages8
Publication statusPublished - 2015


  • AgInS2 quantum dots
  • In vivo imaging
  • Multidentate polymer
  • Near-infrared
  • Hydrates
  • Infrared devices
  • Lanthanum compounds
  • Medical applications
  • Organometallics
  • Biomedical applications
  • Fluorescent nanocrystals
  • In-Vivo imaging
  • Multidentate
  • Near Infrared
  • Near-infrared emissions
  • Photoluminescence imaging
  • Quantum dots emitting
  • Semiconductor quantum dots

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