A new optical method improves fluorescence guided diagnosis of bladder tumor in the outpatient department and reveals significant photo bleaching problems in established inpatients PDD techniques

Lars René Lindvold, Gregers G. Hermann

    Research output: Contribution to journalConference articleResearchpeer-review

    Abstract

    Photo dynamic diagnosis (PDD) is a convenient and well-documented procedure for diagnosis of bladder cancer and tumours using endoscopic techniques. At present, this procedure is available only for routine use in an operating room (OR) and often with substantial photobleaching effects of the photosensitizer. We present a novel optical design of the endoscopic PDD procedure that allows the procedure to be performed in the outpatient department (OPD) and not only in the OR. Thereby, inpatient procedures lasting 1-2 days may be replaced by a few hours lasting procedure in the OPD. Urine blurs the fluorescence during PDD used in the OPD. Urine contains fluorescent metabolites that are excited by blue light giving an opaque green fluorescence confounding the desired red fluorescence (PDD) from the tumour tissue. Measurements from the clinical situation has shown that some systems for PPD based on blue light illumination (PDD mode) and white light illumination used for bladder tumour diagnosis and surgery suffers some inherent disadvantages, i.e., photo bleaching in white light that impairs the possibility for PDD as white light usually is used before the blue light for PDD. Based on spectroscopic observations of urine and the photoactive dye Protoporphyrin IX used in PDD a novel optical system for use with the cystoscope has been devised that solves the problem of green fluorescence from urine. This and the knowledge of photo-bleaching pitfalls in established systems make it possible to perform PDD of bladder tumours in the OPD and to improve PDD in the OR. © 2013 SPIE.
    Original languageEnglish
    JournalProceedings of SPIE, the International Society for Optical Engineering
    Volume8565
    Pages (from-to)856517
    ISSN1605-7422
    DOIs
    Publication statusPublished - 2013
    EventPhotonic Therapeutics and Diagnostics IX - San Francisco, CA, United States
    Duration: 2 Feb 20137 Feb 2013
    Conference number: 9

    Conference

    ConferencePhotonic Therapeutics and Diagnostics IX
    Number9
    CountryUnited States
    CitySan Francisco, CA
    Period02/02/201307/02/2013

    Keywords

    • Bleaching
    • Body fluids
    • Cleaning
    • Diseases
    • Endoscopy
    • Hospitals
    • Optical design
    • Optical systems
    • Photobleaching
    • Photosensitizers
    • Tumors
    • Fluorescence
    • Bladder cancer
    • Photo dynamic diagnosis
    • Autofluorescence
    • Bladder cancers
    • Clinical situations
    • Green fluorescence
    • Outpatient departments
    • Photobleaching effect
    • White-light illumination

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